Reactome | Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

Stable Identifier

R-HSA-192312

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (Homo sapiens)
        
        Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate (Homo sapiens)

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Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate, releasing CoASH. This reaction, which completes the de novo synthesis of bile salts from cholesterol in vivo, is catalyzed by BAAT (Bile acid CoA:amino acid N-acyltransferase - Falany et al. 1994) and occurs in the peroxisomal matrix (Solaas et al. 2000; Mihalik et al. 2002). In vivo, the relative amounts of glycocholate and taurocholate synthesized appear to be determined solely by the intracellular abundances of glycine and taurine (Russell 2003).

Literature References

PubMed ID	Title	Journal	Year
8034703	Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. Barnes, S, Johnson, MR, Diasio, RB, Falany, CN	J Biol Chem	1994