Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

Stable Identifier
R-HSA-192312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate, releasing CoASH. This reaction, which completes the de novo synthesis of bile salts from cholesterol in vivo, is catalyzed by BAAT (Bile acid CoA:amino acid N-acyltransferase - Falany et al. 1994) and occurs in the peroxisomal matrix (Solaas et al. 2000; Mihalik et al. 2002). In vivo, the relative amounts of glycocholate and taurocholate synthesized appear to be determined solely by the intracellular abundances of glycine and taurine (Russell 2003).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transferase activity, transferring acyl groups of BAAT [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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