Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate

Stable Identifier
R-HSA-192312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate, releasing CoASH. This reaction, which completes the de novo synthesis of bile salts from cholesterol in vivo, is catalyzed by BAAT (Bile acid CoA:amino acid N-acyltransferase - Falany et al. 1994) and occurs in the peroxisomal matrix (Solaas et al. 2000; Mihalik et al. 2002). In vivo, the relative amounts of glycocholate and taurocholate synthesized appear to be determined solely by the intracellular abundances of glycine and taurine (Russell 2003).
Literature References
Participants
Participates
Catalyst Activity

acyltransferase activity of BAAT [peroxisomal matrix]

Orthologous Events
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