Reactome | HSD3B1 [endoplasmic reticulum membrane]

HSD3B1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-192072

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-beta-HSD I, 3 beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I, 3BH1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14060 HSD3B1

Gene Names

HSD3B1, 3BH, HSDB3A

Chain

initiator methionine:, chain:2-373

Reference Genes

BioGPS Gene:3283 HSD3B1

COSMIC (genes):HSD3B1 HSD3B1

CTD Gene:3283 HSD3B1

dbSNP Gene:3283 HSD3B1

ENSEMBL:ENSG00000203857 HSD3B1

ENSEMBL_homo_sapiens_GENE:ENSG00000203857.10 HSD3B1

HGNC:5217 HSD3B1

KEGG Gene (Homo sapiens):3283 HSD3B1

Monarch:3283 HSD3B1

NCBI Gene:3283 HSD3B1

OMIM:109715 HSD3B1

UCSC:P14060 HSD3B1

Reference Transcript

Other Identifiers

11739252_x_at

204515_PM_at

204515_at

2354446

2354447

2354543

2354554

2354555

2354556

2354557

2354558

2354559

2354563

2354564

2354567

2354568

2354569

2354570

2354607

3283

35721_at

7904414

7904421

A_23_P97173

GE57961

GO:0000253

GO:0003824

GO:0003854

GO:0004769

GO:0005515

GO:0005634

GO:0005730

GO:0005737

GO:0005739

GO:0005743

GO:0005758

GO:0005783

GO:0005789

GO:0006629

GO:0006694

GO:0006702

GO:0006703

GO:0008152

GO:0008202

GO:0008207

GO:0016020

GO:0016491

GO:0016616

GO:0016853

GO:0021766

GO:0030868

GO:0031966

GO:0043226

GO:0043231

GO:0045171

GO:0047024

GO:0048856

GO:0051412

GO:0102294

HMNXSV003009695

ILMN_1780693

M38180_rna1_at

PH_hs_0032869

TC01001040.hg

g4504506_3p_at

Participates

as a component of

HSD3B1 homodimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

HSD3B1 [endoplasmic reticulum membrane] (Bos taurus)

HSD3B1 [endoplasmic reticulum membrane] (Canis familiaris)

HSD3B1 [endoplasmic reticulum membrane] (Gallus gallus)

HSD3B1 [endoplasmic reticulum membrane] (Mus musculus)

HSD3B1 [endoplasmic reticulum membrane] (Rattus norvegicus)

HSD3B1 [endoplasmic reticulum membrane] (Sus scrofa)

cb723 [endoplasmic reticulum membrane] (Danio rerio)

Homologues of HSD3B1 [endoplasmic reticulum membrane] (Mus musculus)

Cross References

RefSeq

NP_000853.1, NP_001315544.1

OpenTargets

ENSG00000203857

IntEnz

1.1.1.270, 5.3.3.1, 1.1.1.210, 1.1.1.145

GeneCards

P14060

HPA

ENSG00000203857-HSD3B1

ZINC - Substances

3BHS1_HUMAN

ZINC target

P14060

Ensembl

ENSP00000432268, ENSG00000203857, ENST00000528909, ENSP00000358421, ENST00000369413

PRO

P14060

Pharos - Targets

P14060

ZINC - Predictions - Purchasable

3BHS1_HUMAN

HMDB Protein

HMDBP04403

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36957 DLST	4	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3

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