Reactome | CYP46A1 24-hydroxylates CHOL

CYP46A1 24-hydroxylates CHOL

Stable Identifier

R-HSA-192061

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

cholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-hydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase), cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP46A1 24-hydroxylates CHOL (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Bile acid and bile salt metabolism (Homo sapiens)
      - Synthesis of bile acids and bile salts (Homo sapiens)
        
        Synthesis of bile acids and bile salts via 24-hydroxycholesterol (Homo sapiens)
        
        CYP46A1 24-hydroxylates CHOL (Homo sapiens)

General

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Cholesterol 24-hydroxylase (CYP46A1), an enzyme associated with the ER membrane, catalyses the 24-hydroxylation of cholesterol (CHOL) to 24-hydroxycholesterol (24OH-CHOL). In the body, this enzyme is expressed predominantly in the brain and is thought to play a major role in cholesterol turnover there (Lund et al. 1999, Mast et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
14640697	Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain Mast, N, Norcross, R, Andersson, U, Shou, M, Nakayama, K, Bjorkhem, I, Pikuleva, IA	Biochemistry	2003
10377398	cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain Lund, EG, Guileyardo, JM, Russell, DW	Proc Natl Acad Sci U S A	1999