CYP46A1 24-hydroxylates CHOL

Stable Identifier
R-HSA-192061
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cholesterol + NADPH + H+ + O2 => 24-hydroxycholesterol + NADP+ + H2O
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Cholesterol 24-hydroxylase (CYP46A1), an enzyme associated with the ER membrane, catalyses the 24-hydroxylation of cholesterol (CHOL) to 24-hydroxycholesterol (24OH-CHOL). In the body, this enzyme is expressed predominantly in the brain and is thought to play a major role in cholesterol turnover there (Lund et al. 1999, Mast et al. 2003).

Literature References
PubMed ID Title Journal Year
10377398 cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

Lund, EG, Guileyardo, JM, Russell, DW

Proc Natl Acad Sci U S A 1999
14640697 Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain

Mast, N, Norcross, R, Andersson, U, Shou, M, Nakayama, K, Bjorkhem, I, Pikuleva, IA

Biochemistry 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cholesterol 24-hydroxylase activity of CYP46A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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