THCA is translocated from the mitochondrial matrix to the cytosol

Stable Identifier
R-HSA-191971
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
THCA [mitochondrial matrix] => THCA [cytosol]
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THCA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate) is translocated from the mitochondrial matrix to the cytosol. The transporter that mediates its passage across the inner mitochondrial membrane has not been identified. In particular, despite the structural and functional similarities between THCA and long chain fatty acids, searches for carnitine - THCA have failed (Russell 2003). VLCS (SLC27A2), one of the enzymes that catalyzes CoA conjugation of THCA may also be present in peroxisomes, and Mihalik et al. (2002) have hypothesized that THCA could be translocated unchanged from the mitochondrial matrix to the peroxisomal matrix and undergo conjugation there.

Literature References
PubMed ID Title Journal Year
12543708 The enzymes, regulation, and genetics of bile acid synthesis

Russell, DW

Annu Rev Biochem 2003
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