CHIP (STUB1) mediates ubiquitination of ERBB2

Stable Identifier
R-HSA-1918092
Type
Reaction
Species
Homo sapiens
Compartment
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E3 ubiquitin ligase CHIP (STUB1) mediates ERBB2 ubiquitination by associating with the ERBB2 indirectly, through the chaperone protein HSP90. CHIP (STUB1) ubiquitinates both ERBB2 and HSP90, leading to their proteasome-dependent degradation. Ubiquitination of ERBB2 by CHIP (STUB1) is independent of ERBB2 activation.

Literature References
PubMed ID Title Journal Year
12239347 Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/Neu

Mimnaugh, E, Yuan, X, Neckers, LM, Marcu, M, Xu, W, Patterson, C

Proc Natl Acad Sci U S A 2002
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of STUB1 [cytosol]

Orthologous Events
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