snRNP:Snurportin complex formation

Stable Identifier
R-HSA-191763
Type
Reaction [binding]
Species
Homo sapiens
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The nuclear import signal has two parts; Cap hypermethylation triggers nuclear import via snurportin1 binding and by receptor recognition of the Sm proteins. Snurportin1 (SPN) is an adaptor that links the assembled snRNP to the nuclear transport machinery, recruiting importin beta for nuclear import. The import receptor that recognizes the Sm proteins is not yet known.

Literature References
PubMed ID Title Journal Year
12095920 SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta

Narayanan, U, Ospina, JK, Frey, MR, Hebert, MD, Matera, AG

Hum Mol Genet 2002
12776181 Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron

Mouaikel, J, Narayanan, U, Verheggen, C, Matera, AG, Bertrand, E, Tazi, J, Bordonne, R

EMBO Rep 2003
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