Reactome | snRNP:Snurportin complex formation

snRNP:Snurportin complex formation

Stable Identifier

R-HSA-191763

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The nuclear import signal has two parts; Cap hypermethylation triggers nuclear import via snurportin1 binding and by receptor recognition of the Sm proteins. Snurportin1 (SPN) is an adaptor that links the assembled snRNP to the nuclear transport machinery, recruiting importin beta for nuclear import. The import receptor that recognizes the Sm proteins is not yet known.

Literature References

PubMed ID	Title	Journal	Year
12776181	Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron Mouaikel, J, Narayanan, U, Verheggen, C, Matera, AG, Bertrand, E, Tazi, J, Bordonne, R	EMBO Rep	2003
12095920	SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta Narayanan, U, Ospina, JK, Frey, MR, Hebert, MD, Matera, AG	Hum Mol Genet	2002