Reactome | c-src associates with Cx43 in gap junctions

c-src associates with Cx43 in gap junctions

Stable Identifier

R-HSA-191654

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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c-src associates with Cx43 in gap junctions

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c-src has been shown to interact with Cx43 (Giepmans et al., 2001). Models describing v-src mediated Cx43 channel gating propose that the initial interaction between v-src and Cx43 may occur via a SH3 domain interaction (see Lau 2005).

Literature References

PubMed ID	Title	Journal	Year
11124251	Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. Giepmans, BN, Hengeveld, T, Postma, FR, Moolenaar, WH	J Biol Chem	2001