c-src associates with Cx43 in gap junctions

Stable Identifier
R-HSA-191654
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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c-src associates with Cx43 in gap junctions
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c-src has been shown to interact with Cx43 (Giepmans et al., 2001). Models describing v-src mediated Cx43 channel gating propose that the initial interaction between v-src and Cx43 may occur via a SH3 domain interaction (see Lau 2005).
Literature References
PubMed ID Title Journal Year
11124251 Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication.

Moolenaar, WH, Giepmans, BN, Hengeveld, T, Postma, FR

J Biol Chem 2001
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Orthologous Events
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Authored
Gilleron, J  (2007-01-03)
Segretain, D  (2007-01-03)
Falk, MM  (2007-01-03)
Created
Matthews, L  (2007-01-23)
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