c-src associates with Cx43 in gap junctions

Stable Identifier
R-HSA-191654
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
c-src associates with Cx43 in gap junctions
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

c-src has been shown to interact with Cx43 (Giepmans et al., 2001). Models describing v-src mediated Cx43 channel gating propose that the initial interaction between v-src and Cx43 may occur via a SH3 domain interaction (see Lau 2005).

Literature References
PubMed ID Title Journal Year
11124251 Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication.

Giepmans, BN, Hengeveld, T, Postma, FR, Moolenaar, WH

J Biol Chem 2001
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
c-src associates with Cx43 in gap junctions (Bos taurus)
c-src associates with Cx43 in gap junctions (Danio rerio)
c-src associates with Cx43 in gap junctions (Mus musculus)
c-src associates with Cx43 in gap junctions (Rattus norvegicus)
c-src associates with Cx43 in gap junctions (Sus scrofa)
c-src associates with Cx43 in gap junctions (Xenopus tropicalis)
Authored
Gilleron, J  (2007-01-03)
Segretain, D  (2007-01-03)
Falk, MM  (2007-01-03)
Created
Matthews, L  (2007-01-23)