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FRS3 [plasma membrane]
Stable Identifier
R-HSA-191482
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
FRS2-beta
Locations in the PathwayBrowser for interactor UniProt:Q8NEC5 CATSPER1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1 binds FRS3 (Homo sapiens)
FRS3 [plasma membrane] (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
Downstream signaling of activated FGFR2 (Homo sapiens)
FRS-mediated FGFR2 signaling (Homo sapiens)
Activated FGFR2 binds FRS3 (Homo sapiens)
FRS3 [plasma membrane] (Homo sapiens)
Signaling by FGFR3 (Homo sapiens)
Downstream signaling of activated FGFR3 (Homo sapiens)
FRS-mediated FGFR3 signaling (Homo sapiens)
Activated FGFR3 binds FRS3 (Homo sapiens)
FRS3 [plasma membrane] (Homo sapiens)
Signaling by FGFR4 (Homo sapiens)
Downstream signaling of activated FGFR4 (Homo sapiens)
FRS-mediated FGFR4 signaling (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
FRS3 [plasma membrane] (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through FRS2 and FRS3 (Homo sapiens)
Activated NTRK2 binds FRS3 (Homo sapiens)
FRS3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43559 FRS3
Gene Names
FRS3
Chain
initiator methionine:, chain:2-492
Reference Genes
BioGPS Gene:10817 FRS3
COSMIC (genes):FRS3 FRS3
CTD Gene:10817 FRS3
dbSNP Gene:10817 FRS3
ENSEMBL:ENSG00000137218 FRS3
ENSEMBL_homo_sapiens_GENE:ENSG00000137218.10 FRS3
HGNC:16970 FRS3
KEGG Gene (Homo sapiens):10817 FRS3
Monarch:10817 FRS3
NCBI Gene:10817 FRS3
OMIM:607744 FRS3
UCSC:O43559 FRS3
Reference Transcript
RefSeq:XM_011514255.2 FRS3
RefSeq:NM_006653.4 FRS3
RefSeq:XM_011514254.2 FRS3
Other Identifiers
10817
11727216_at
17019121
219907_PM_at
219907_at
2953778
2953779
2953780
2953782
2953783
2953786
2953788
2953790
8126337
83768_at
A_23_P167970
A_33_P3270295
GE62391
GO:0005068
GO:0005104
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0008543
GO:0016020
GO:0023052
GO:0042802
GO:0060090
HMNXSV003013050
ILMN_1772605
PH_hs_0011463
TC06001723.hg
g5730058_3p_at
Participates
as a member of
RND2 effectors [cytosol] (Homo sapiens)
RND1 effectors [cytosol] (Homo sapiens)
FRS2,3 [plasma membrane] (Homo sapiens)
as a component of
BDNF:p-5Y-Ntrk2 homodimer:FRS3 [plasma membrane] (Homo sapiens)
BDNF,NTF4:p-5Y-NTRK2:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR4:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR2:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR3:FRS3 [plasma membrane] (Homo sapiens)
as an input of
Activated Ntrk2 binds FRS3 (Homo sapiens)
Activated NTRK2 binds FRS3 (Homo sapiens)
Activated FGFR1 binds FRS3 (Homo sapiens)
Activated FGFR4 binds FRS3 (Homo sapiens)
Activated FGFR2 binds FRS3 (Homo sapiens)
Activated FGFR3 binds FRS3 (Homo sapiens)
Other forms of this molecule
p-5Y-FRS3 [plasma membrane]
p-Y-FRS3 [plasma membrane]
Inferred To
Frs3 [plasma membrane]
(Mus musculus)
Frs3 [plasma membrane]
(Rattus norvegicus)
Dmel\CG13398 [plasma membrane]
(Drosophila melanogaster)
frs3 [plasma membrane]
(Danio rerio)
frs3 [plasma membrane]
(Xenopus tropicalis)
FRS3 [plasma membrane]
(Bos taurus)
FRS3 [plasma membrane]
(Canis familiaris)
FRS3 [plasma membrane]
(Gallus gallus)
FRS3 [plasma membrane]
(Sus scrofa)
Ghost homologue of FRS3 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_011512556.1
,
XP_011512557.1
,
NP_006644.1
OpenTargets
ENSG00000137218
HPA
ENSG00000137218-FRS3
GeneCards
O43559
Ensembl
ENST00000259748
,
ENSP00000259748
,
ENSG00000137218
,
ENSP00000362109
,
ENST00000373018
PRO
O43559
Pharos - Targets
O43559
PDB
2YT2
,
2KUP
,
2KUQ
,
2YS5
Interactors (106)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15654 TRIP6
0.718
6
UniProt:Q8HWS3 RFX6
1
RFX6 [nucleoplasm]
(R-HSA-8931801)
0.718
6
UniProt:O43559 FRS3
3
p-5Y-FRS3 [plasma membrane]
(R-HSA-191475)
FRS3 [plasma membrane]
(R-HSA-191482)
p-Y-FRS3 [plasma membrane]
(R-HSA-9032427)
0.703
5
UniProt:Q9WMX2-PRO_0000037548
0.57
3
UniProt:Q92569 PIK3R3
2
PIK3R3 [cytosol]
(R-HSA-205223)
K63polyUb-PIK3R3 [cytosol]
(R-HSA-3080574)
0.57
3
UniProt:Q9H079 KTBL1
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:Q8WVV4-1 POF1B
0.556
3
UniProt:Q9UFD9 RIM3A
0.556
3
UniProt:Q02363 ID2
1
ID2 [nucleoplasm]
(R-HSA-452391)
0.556
3
UniProt:P27658 COL8A1
20
3x4Hyp-3Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173246)
GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173055)
3x4Hyp-GalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173183)
3x4Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173195)
3x4Hyp-3Hyp-GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173270)
GlcGalHyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173122)
COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2172239)
3x4Hyp-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2172948)
3x4Hyp-3Hyp-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2172976)
3x4Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173143)
3x4Hyp-3Hyp-5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173217)
5Hyl-COL8A1(28-744) [endoplasmic reticulum lumen]
(R-HSA-2173023)
3x4Hyp-3Hyp-COL8A1(28-?) [extracellular region]
(R-HSA-2470362)
GalHyl-COL8A1(?-744) [extracellular region]
(R-HSA-2470331)
3x4Hyp-3Hyp-COL8A1(?-744) [extracellular region]
(R-HSA-2470328)
3x4Hyp-3Hyp-GalHyl-COL8A1(?-744) [extracellular region]
(R-HSA-2470329)
3x4Hyp-5Hyl-COL8A1(?-744) [extracellular region]
(R-HSA-2470366)
GalHyl-COL8A1(28-?) [extracellular region]
(R-HSA-2470364)
5Hyl-COL8A1(?-744) [extracellular region]
(R-HSA-2470333)
COL8A1(?-744) [extracellular region]
(R-HSA-2470355)
0.556
3
UniProt:Q6ZU52 K0408
0.556
3
UniProt:Q9BYR7 KRTAP3-2
1
KRTAP3-2 [cytosol]
(R-HSA-6809857)
0.556
3
UniProt:A8MV65-2 VGLL3
0.556
3
UniProt:Q9BYR8 KRTAP3-1
1
KRTAP3-1 [cytosol]
(R-HSA-6809868)
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:Q7Z5V6-2 SAXO4
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q3KP44 ANR55
0.556
3
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.556
3
UniProt:Q02535 ID3
1
ID3 [nucleoplasm]
(R-HSA-9613379)
0.556
3
UniProt:Q8TF47 ZFP90
1
ZFP90 [nucleoplasm]
(R-HSA-974988)
0.556
3
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:Q08117-2 TLE5
0.556
5
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9BWG6 SCNM1
0.556
3
UniProt:Q9NQX0 PRDM6
0.556
3
UniProt:P15976 GATA1
1
GATA1 [nucleoplasm]
(R-HSA-996772)
0.556
3
UniProt:Q9NWS9-2 ZNF446
0.556
3
IntAct:EBI-22384931 CCSB ORF ID
0.556
3
UniProt:Q9UC07-2 ZNF69
0.556
3
UniProt:Q5BKX5-3 ACTMAP
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:O75716 STK16
0.556
3
UniProt:Q9NYG5-2 ANAPC11
0.556
3
UniProt:Q6NVV7 CDPF1
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:O76011 KRT34
1
KRT34 [cytosol]
(R-HSA-6809608)
0.556
5
UniProt:A2VCK2 DCD2B
0.556
3
UniProt:Q01546 KRT76
1
KRT76 [cytosol]
(R-HSA-6809633)
0.556
3
UniProt:Q8IWL8 STH
0.556
3
UniProt:Q9BUZ4 TRAF4
0.556
3
UniProt:Q3SY00 T10IP
0.556
3
UniProt:Q9Y6H3 ATP23
0.556
3
IntAct:EBI-22320813 CCSB ORF ID
0.556
3
UniProt:Q8NF64-3 ZMIZ2
0.556
3
UniProt:Q8ND83 SLAI1
0.556
3
UniProt:Q86WV8 Q86WV8
0.556
3
UniProt:P48745 CCN3
0.556
3
UniProt:Q9UNS2 COPS3
2
COPS3 [cytosol]
(R-HSA-416973)
COPS3 [nucleoplasm]
(R-HSA-5697017)
0.556
3
UniProt:Q99932-2 SPAG8
0.556
3
UniProt:Q3LI66 KRTAP6-2
1
KRTAP6-2 [cytosol]
(R-HSA-6810261)
0.556
5
UniProt:P15976-2 GATA1
0.556
5
UniProt:Q8N1D0-2 SLC22A18AS
0.556
3
UniProt:Q5T749 KPRP
1
KPRP [cytosol]
(R-HSA-9839614)
0.556
5
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.556
3
UniProt:Q9H707 ZNF552
1
ZNF552 [nucleoplasm]
(R-HSA-1973877)
0.556
3
UniProt:Q8N456 LRC18
0.556
3
UniProt:Q8TAV5 KC5S1
0.556
3
UniProt:O14817 TSN4
0.556
3
UniProt:Q9NQL9 DMRT3
0.556
3
UniProt:Q6P5X5 CV039
0.556
3
UniProt:Q96FE5 LINGO1
1
LINGO1 [plasma membrane]
(R-HSA-3006563)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q8WWY6 MB3L1
0.556
3
UniProt:Q02930-3 CREB5
0.556
3
UniProt:Q9H5F2 CFA68
0.556
3
IntAct:EBI-16439879 CCSB ORF ID
0.556
3
UniProt:Q9NQ30 ESM1
0.556
3
UniProt:Q9ULR0-1 Q9ULR01
0.556
3
UniProt:Q5JXC2 MIIP
0.556
3
UniProt:Q16610 ECM1
2
ECM1 [extracellular region]
(R-HSA-8848909)
ECM1 [platelet dense granule lumen]
(R-HSA-8848880)
0.556
3
UniProt:Q8IUC1 KRTAP11-1
1
KRTAP11-1 [cytosol]
(R-HSA-6810294)
0.556
3
UniProt:Q6IA69 NADSYN1
1
NADSYN1 [cytosol]
(R-HSA-197231)
0.556
3
UniProt:P35452-2 P354522
0.556
3
UniProt:Q9NZC7-5 WWOX
0.556
3
UniProt:Q8TDR4 TCP1L
0.556
3
UniProt:Q92824-2 PCSK5
0.556
3
UniProt:Q15973 ZNF124
1
ZNF124 [nucleoplasm]
(R-HSA-975017)
0.556
3
UniProt:Q9H9P5-5 UNKL
0.556
3
UniProt:Q14525 KRT33B
1
KRT33B [cytosol]
(R-HSA-6809594)
0.556
3
UniProt:Q96PF1 TGM7
0.556
3
UniProt:Q9Y342 PLLP
0.556
3
UniProt:A0A0U1RQF7 DP2NB
0.556
3
UniProt:P15884 TCF4
1
TCF4 [nucleoplasm]
(R-HSA-445672)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
1
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
0.556
3
UniProt:O15162 PLS1
0.556
3
UniProt:Q9BRX9 WDR83
1
WDR83 [endosome membrane]
(R-HSA-5672942)
0.556
3
UniProt:Q6P1J6-2 PLB1
0.556
3
UniProt:Q7Z6I5 SPT12
0.556
3
UniProt:Q8NA61 CBY2
0.556
3
UniProt:Q0VD86 INCA1
0.556
3
UniProt:Q86W11 ZSC30
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q7Z4V0 ZN438
0.556
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.556
3
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.556
7
UniProt:O43597 SPRY2
8
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
SPRY2 [cytosol]
(R-HSA-182949)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
0.556
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.556
3
UniProt:P08631-2 HCK
0.508
2
UniProt:Q8WXH5 SOCS4
1
SOCS4 [cytosol]
(R-HSA-8936109)
0.508
2
UniProt:P42679 MATK
1
MATK [cytosol]
(R-HSA-1433581)
0.488
2
UniProt:P49757 NUMB
1
NUMB [plasma membrane]
(R-HSA-443595)
0.488
2
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.488
2
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