Reactome | HMGCR-2 [endoplasmic reticulum membrane]

HMGCR-2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-191426

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

3-hydroxy-3-methylglutaryl-coenzyme A reductase-2, HMDH_HUMAN, HMGCR isoform 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04035-2 HMGCR

Gene Names

HMGCR

Participates

as a member of

Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

HMG1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

hmgcra [endoplasmic reticulum membrane] (Danio rerio)

HMGCR [endoplasmic reticulum membrane] (Bos taurus)

HMGCR [endoplasmic reticulum membrane] (Canis familiaris)

HMGCR [endoplasmic reticulum membrane] (Sus scrofa)

Hmgcr [endoplasmic reticulum membrane] (Drosophila melanogaster)

Hmgcr [endoplasmic reticulum membrane] (Mus musculus)

Hmgcr [endoplasmic reticulum membrane] (Rattus norvegicus)

hmg1 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

hmgr-1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

HMGCR-1 [endoplasmic reticulum membrane] (Gallus gallus)

hmgA [endoplasmic reticulum membrane] (Dictyostelium discoideum)

hmgcr [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001351116.1, XP_011541659.1, NP_000850.1, NP_001124468.1, XP_054208459.1, XP_054208460.1, XP_011541660.1

ZINC - World Drugs

HMDH_HUMAN

Guide to Pharmacology - Targets

639

OpenTargets

ENSG00000113161

ENSEMBL

ENSP00000505805, ENSP00000340816, ENST00000511206, ENST00000343975, ENST00000681410, ENSP00000505561, ENSP00000426745, ENSP00000287936, ENST00000681271, ENSG00000113161, ENSP00000506232, ENST00000680940, ENST00000287936

ZINC - FDA approved

HMDH_HUMAN

ZINC - Substances

HMDH_HUMAN

ZINC - Biogenic

HMDH_HUMAN

ZINC target

P04035

PRO

P04035

GlyGen

P04035

PDB

1DQA, 3CD5, 3CCT, 2Q6C, 1HWK, 2Q6B, 3CCZ, 1HWI, 1HWJ, 1DQ9, 3CD0, 1DQ8, 2Q1L, 1HW8, 1HW9, 2R4F, 3CD7, 3BGL, 3CCW, 3CDA, 3CDB, 1HWL

ZINC - Metabolites

HMDH_HUMAN

HPA

ENSG00000113161-HMGCR

GeneCards

HMGCR

Pharos - Targets

P04035

ZINC - Predictions - Purchasable

HMDH_HUMAN

HMDB Protein

HMDBP00910

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.621	4
UniProt:P51684 CCR6	1	CCR6 [plasma membrane] (R-HSA-373089)	0.527	2
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 P345Pfs103 [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 L230Afs188 [endoplasmic reticulum membrane] (R-HSA-9628869)	0.527	2
UniProt:Q86VZ1 P2RY8			0.527	2
UniProt:Q13304 GPR17	1	GPR17 [plasma membrane] (R-HSA-416429)	0.527	2
UniProt:P54709 ATP1B3	1	ATP1B3 [plasma membrane] (R-HSA-375073)	0.527	3
UniProt:O14967 CLGN			0.527	2
UniProt:Q7Z5B4 RIC3			0.527	2

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