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HMGCR-2 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-191426
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
3-hydroxy-3-methylglutaryl-coenzyme A reductase-2, HMDH_HUMAN, HMGCR isoform 2
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Cholesterol biosynthesis (Homo sapiens)
HMGCR dimer binds statins (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-2 [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer:statins [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-2 [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR dimer reduces bHMG-CoA to MVA (Homo sapiens)
HMGCR dimer [endoplasmic reticulum membrane] (Homo sapiens)
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
HMGCR-2 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04035-2 HMGCR
Gene Names
HMGCR
Participates
as a member of
Hydroxymethyl glutaryl CoA reductase [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
HMG1 [endoplasmic reticulum membrane]
(Saccharomyces cerevisiae)
hmgcra [endoplasmic reticulum membrane]
(Danio rerio)
HMGCR [endoplasmic reticulum membrane]
(Bos taurus)
HMGCR [endoplasmic reticulum membrane]
(Canis familiaris)
HMGCR [endoplasmic reticulum membrane]
(Sus scrofa)
Hmgcr [endoplasmic reticulum membrane]
(Drosophila melanogaster)
Hmgcr [endoplasmic reticulum membrane]
(Mus musculus)
Hmgcr [endoplasmic reticulum membrane]
(Rattus norvegicus)
hmg1 [endoplasmic reticulum membrane]
(Schizosaccharomyces pombe)
hmgr-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
HMGCR-1 [endoplasmic reticulum membrane]
(Gallus gallus)
hmgA [endoplasmic reticulum membrane]
(Dictyostelium discoideum)
hmgcr [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001351116.1
,
XP_011541659.1
,
NP_000850.1
,
NP_001124468.1
,
XP_054208459.1
,
XP_054208460.1
,
XP_011541660.1
ZINC - World Drugs
HMDH_HUMAN
Guide to Pharmacology - Targets
639
OpenTargets
ENSG00000113161
ENSEMBL
ENSP00000505805
,
ENSP00000340816
,
ENST00000511206
,
ENST00000343975
,
ENST00000681410
,
ENSP00000505561
,
ENSP00000426745
,
ENSP00000287936
,
ENST00000681271
,
ENSG00000113161
,
ENSP00000506232
,
ENST00000680940
,
ENST00000287936
ZINC - FDA approved
HMDH_HUMAN
ZINC - Substances
HMDH_HUMAN
ZINC - Biogenic
HMDH_HUMAN
ZINC target
P04035
PRO
P04035
GlyGen
P04035
PDB
1DQA
,
3CD5
,
3CCT
,
2Q6C
,
1HWK
,
2Q6B
,
3CCZ
,
1HWI
,
1HWJ
,
1DQ9
,
3CD0
,
1DQ8
,
2Q1L
,
1HW8
,
1HW9
,
2R4F
,
3CD7
,
3BGL
,
3CCW
,
3CDA
,
3CDB
,
1HWL
ZINC - Metabolites
HMDH_HUMAN
HPA
ENSG00000113161-HMGCR
GeneCards
HMGCR
Pharos - Targets
P04035
ZINC - Predictions - Purchasable
HMDH_HUMAN
HMDB Protein
HMDBP00910
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5Z9 UBIAD1
1
UBIAD1 [endoplasmic reticulum membrane]
(R-HSA-2980965)
0.621
4
UniProt:P51684 CCR6
1
CCR6 [plasma membrane]
(R-HSA-373089)
0.527
2
UniProt:Q9H1C4 UNC93B1
4
UNC93B1 [Golgi membrane]
(R-HSA-1679064)
UNC93B1 [endoplasmic reticulum membrane]
(R-HSA-1678930)
UNC93B1 P345Pfs*103 [endoplasmic reticulum membrane]
(R-HSA-9628866)
UNC93B1 L230Afs*188 [endoplasmic reticulum membrane]
(R-HSA-9628869)
0.527
2
UniProt:Q86VZ1 P2RY8
0.527
2
UniProt:Q13304 GPR17
1
GPR17 [plasma membrane]
(R-HSA-416429)
0.527
2
UniProt:P54709 ATP1B3
1
ATP1B3 [plasma membrane]
(R-HSA-375073)
0.527
3
UniProt:O14967 CLGN
0.527
2
UniProt:Q7Z5B4 RIC3
0.527
2
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