Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate

Stable Identifier
R-HSA-191382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
isopentenyl diphosphate => dimethylallyl diphosphate
ReviewStatus
5/5
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Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate
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Cytosolic Isopentenyl-diphosphate delta-isomerase isoforms 1 and 2 (IDI1 or 2)) catalyze an essential activation step in the isoprenoid biosynthetic pathway, rearranging isopentenyl pyrophosphate (IPPP) into its highly electrophilic isomer, dimethylallyl pyrophosphate (DMAPP) (Hahn et al. 1996). IPP isomerase may also be located in human peroxisomes but its function there is not clear.
Literature References
PubMed ID Title Journal Year
8806705 Human isopentenyl diphosphate: dimethylallyl diphosphate isomerase: overproduction, purification, and characterization

Hahn, FM, Xuan, JW, Chambers, AF, Poulter, CD

Arch Biochem Biophys 1996
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Catalyst Activity

isopentenyl-diphosphate delta-isomerase activity of IDI1 or 2 [cytosol]

Physical Entity
IDI1 or 2 [cytosol] (Homo sapiens)
Activity
isopentenyl-diphosphate delta-isomerase activity (GO:0004452)
Orthologous Events
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Bos taurus)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Caenorhabditis elegans)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Canis familiaris)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Danio rerio)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Dictyostelium discoideum)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Drosophila melanogaster)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Gallus gallus)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Mus musculus)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Rattus norvegicus)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Saccharomyces cerevisiae)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Schizosaccharomyces pombe)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Sus scrofa)
Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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