NOTCH3 mRNA translation controlled by miRNAs

Stable Identifier
R-HSA-1912409
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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NOTCH3 mRNA translation controlled by miRNAs
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Translation of NOTCH3 mRNA is negatively regulated by miR-150 (Ghisi et al. 2011) and miR-206 microRNAs (Song et al. 2009). These miRNAs bind and cause degradation of NOTCH3 mRNA, resulting in decreased level of NOTCH3 protein product.
Literature References
PubMed ID Title Journal Year
19723635 MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation

Song, G, Wang, L, Zhang, Y

J Biol Chem 2009
21551231 Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150

Bronte, V, Indraccolo, S, Basso, G, Gerosa, G, D'Agostino, DM, Amadori, A, Mussolin, L, Guffanti, A, Basso, K, De Bellis, G, Stellin, G, Ruggero, K, Ghisi, M, Frasson, C, Zanovello, P, Mukherjee, S, Corradin, A, Bonanno, L, Serafin, V

Blood 2011
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NOTCH3 mRNA:miR-206 RISC [cytosol] (Homo sapiens)
Active Unit
miR-206 RISC [cytosol]
Regulator
NOTCH3 mRNA:miR-150 RISC [cytosol] (Homo sapiens)
Active Unit
miR-150 RISC [cytosol]
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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