NOTCH3 mRNA translation controlled by miRNAs

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Reaction [omitted]
Homo sapiens
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Translation of NOTCH3 mRNA is negatively regulated by miR-150 (Ghisi et al. 2011) and miR-206 microRNAs (Song et al. 2009). These miRNAs bind and cause degradation of NOTCH3 mRNA, resulting in decreased level of NOTCH3 protein product.

Literature References
PubMed ID Title Journal Year
21551231 Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150

Ghisi, M, Corradin, A, Basso, K, Frasson, C, Serafin, V, Mukherjee, S, Mussolin, L, Ruggero, K, Bonanno, L, Guffanti, A, De Bellis, G, Gerosa, G, Stellin, G, D'Agostino, DM, Basso, G, Bronte, V, Indraccolo, S, Amadori, A, Zanovello, P

Blood 2011
19723635 MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation

Song, G, Zhang, Y, Wang, L

J Biol Chem 2009
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