NOTCH4 gene transcription

Stable Identifier
R-HSA-1912401
Type
Reaction [omitted]
Species
Homo sapiens
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The NOTCH4 gene maps to the short arm of human chromosome 6. High levels of NOTCH4 transcript are detectable in adult heart. NOTCH4 mRNA is also found in lung and placenta, and at low levels in liver, skeletal muscle, kidney, pancreas, spleen, thymus, lymph nodes and bone marrow (Li et al. 1998).

In vascular endothelium, NOTCH4 transcription is activated by c-JUN (AP-1) transcription factor. JUN, likely in complex with other transcription factors, binds AP-1 motif(s) in the NOTCH4 promoter and possibly within the first intron (Wu et al. 2005).

Literature References
PubMed ID Title Journal Year
9693032 Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene

Li, L, Huang, GM, Banta, AB, Deng, Y, Smith, T, Dong, P, Friedman, C, Chen, L, Trask, BJ, Spies, T, Rowen, L, Hood, L

Genomics 1998
15684396 Molecular determinants of NOTCH4 transcription in vascular endothelium

Wu, J, Iwata, F, Grass, JA, Osborne, CS, Elnitski, L, Fraser, P, Ohneda, O, Yamamoto, M, Bresnick, EH

Mol. Cell. Biol. 2005
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