DNER is a transmembrane protein specifically expressed in dendrites and cell bodies of postmitotic neurons. DNER has ten extracellular EGF repeats highly homologous to EGF repeats of Notch and Delta proteins, but does not contain a typical DSL domain. DNER binds NOTCH1 and this interaction involves the first and second EGF repeat of DNER. Activation of NOTCH1 signaling by DNER requires the presence of deltex (DTX1, DTX2 and/or DTX4). The interaction of DNER and NOTCH may be playing an important role in the development of the central nervous system by influencing the differentiation of astrocytes, based on mouse studies.