Ubiquitination of NOTCH1 by ITCH in the absence of ligand

Stable Identifier
R-HSA-1912386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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Ubiquitination of NOTCH1 by ITCH in the absence of ligand
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ITCH, recruited to NOTCH1 indirectly through association with NUMB, ubiquitinates NOTCH1 and targets it for degradation.

Literature References
PubMed ID Title Journal Year
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, Dho, SE, Weinmaster, G, McGlade, CJ

J Biol Chem 2009
18628966 AIP4/Itch regulates Notch receptor degradation in the absence of ligand

Chastagner, P, Israel, A, Brou, C

PLoS One 2008
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of NOTCH1:NUMB:ITCH [plasma membrane]
Physical Entity
NOTCH1:NUMB:ITCH [plasma membrane]
Activity
ubiquitin-protein transferase activity (0004842)
Inferred From
Itch ubiquitinates Notch (Mus musculus)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)