Ubiquitination of NOTCH1 by ITCH in the absence of ligand

Stable Identifier
R-HSA-1912386
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ITCH, recruited to NOTCH1 indirectly through association with NUMB, ubiquitinates NOTCH1 and targets it for degradation.

Literature References
PubMed ID Title Journal Year
18628966 AIP4/Itch regulates Notch receptor degradation in the absence of ligand

Brou, C, Israel, A, Chastagner, P

PLoS One 2008
19567869 Numb regulates post-endocytic trafficking and degradation of Notch1

McGill, MA, McGlade, CJ, Weinmaster, G, Dho, SE

J Biol Chem 2009
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of NOTCH1:NUMB:ITCH [plasma membrane]

Inferred From
Authored
Reviewed
Created
Cite Us!