Reactome | Ubiquitination of NOTCH1 by ITCH in the absence of ligand

Ubiquitination of NOTCH1 by ITCH in the absence of ligand

Stable Identifier

R-HSA-1912386

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Ubiquitination of NOTCH1 by ITCH in the absence of ligand

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ITCH, recruited to NOTCH1 indirectly through association with NUMB, ubiquitinates NOTCH1 and targets it for degradation.

Literature References

PubMed ID	Title	Journal	Year
18628966	AIP4/Itch regulates Notch receptor degradation in the absence of ligand Chastagner, P, Israel, A, Brou, C	PLoS One	2008
19567869	Numb regulates post-endocytic trafficking and degradation of Notch1 McGill, MA, Dho, SE, Weinmaster, G, McGlade, CJ	J Biol Chem	2009