ITCH, recruited to NOTCH1 indirectly through association with NUMB, ubiquitinates NOTCH1 and targets it for degradation.
Brou, C, Israel, A, Chastagner, P
McGill, MA, McGlade, CJ, Weinmaster, G, Dho, SE
ubiquitin-protein transferase activity of NOTCH1:NUMB:ITCH [plasma membrane]
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