Sialylation of Pre-NOTCH

Stable Identifier
R-HSA-1912378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
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Sialylation of Pre-NOTCH
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Mature fringe-modified NOTCH usually has a tetrasaccharide attached to conserved fucosylated serine and threonine residues in EGF repeats. The chemical structure of these tetrasaccharides is Sia-alpha2,3-Gal-beta1,4-GlcNAc-beta1,3-fucitol (Moloney et al. 2000). The identity of sialyltransferase(s) that add sialic acid to galactose remains unknown in this context. Based on the type of chemical bonds in the tetrasaccharide, there are three known Golgi membrane sialyltransferases that could perform this function: ST3GAL3, ST3GAL4, ST3GAL6 (Harduin-Lepers et al. 2001).

Literature References
PubMed ID Title Journal Year
11530204 The human sialyltransferase family

Vallejo-Ruiz, V, Harduin-Lepers, A, Delannoy, P, Samyn-Petit, B, Krzewinski-Recchi, MA, Julien, S

Biochimie 2001
10935626 Fringe is a glycosyltransferase that modifies Notch

Shao, L, Wang, Y, Johnston, SH, Irvine, KD, Stanley, P, Haltiwanger, RS, Moloney, DJ, Wilson, R, Chen, J, Vogt, TF, Panin, VM

Nature 2000
Participants
Input
Output
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as an event of
Catalyst Activity

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL3/4/6 [Golgi membrane]

Physical Entity
ST3GAL3/4/6 [Golgi membrane] (Homo sapiens)
Activity
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity (GO:0003836)
Inferred From
Sialylation of Pre-Notch (Cricetulus griseus)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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