MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA

Stable Identifier
R-HSA-1912367
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Translation of NOTCH2 mRNA is inhibited by MIR34 microRNAs (MIR34A, MIR34B and MIR34C), which bind to the 3'UTR of NOTCH2 mRNA.

Literature References
PubMed ID Title Journal Year
19773441 MicroRNA-34a inhibits glioblastoma growth by targeting multiple oncogenes

Li, Y, Guessous, F, Zhang, Y, DiPierro, C, Kefas, B, Johnson, E, Marcinkiewicz, L, Jiang, J, Yang, Y, Schmittgen, TD, Lopes, B, Schiff, D, Purow, B, Abounader, R

Cancer Res 2009
Participants
Input
Output
Participant Of
hasEvent
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)