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MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
Stable Identifier
R-HSA-1912366
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
MIR206 microRNA binds 3'UTR of NOTCH3 mRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Translation of NOTCH3 mRNA is inhibited by microRNA miR-206 which binds to the 3'UTR of NOTCH3 mRNA.
Literature References
PubMed ID
Title
Journal
Year
19723635
MicroRNA-206 targets notch3, activates apoptosis, and inhibits tumor cell migration and focus formation
Song, G
,
Wang, L
,
Zhang, Y
J Biol Chem
2009
Participants
Input
miR-206 RISC [cytosol]
(Homo sapiens)
NOTCH3 mRNA [cytosol]
(Homo sapiens)
Output
NOTCH3 mRNA:miR-206 RISC [cytosol]
(Homo sapiens)
Participates
as an event of
Pre-NOTCH Transcription and Translation (Homo sapiens)
Authored
Orlic-Milacic, M (2011-11-14)
Egan, SE (2011-11-14)
Reviewed
Haw, R (2012-02-06)
Created
Orlic-Milacic, M (2011-11-02)
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