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MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
Stable Identifier
R-HSA-1912364
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Pre-NOTCH Expression and Processing (Homo sapiens)
Pre-NOTCH Transcription and Translation (Homo sapiens)
MIR181C microRNA binds 3'UTR of NOTCH4 mRNA (Homo sapiens)
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miR-181C microRNA inhibits translation of NOTCH4 mRNA by binding to its 3'UTR. miR181c is a candidate tumor suppressor in gastric cancer.
Literature References
PubMed ID
Title
Journal
Year
20080834
Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
Yuasa, Y
,
Akiyama, Y
,
Shimada, S
,
Hashimoto, Y
,
Otsubo, T
Carcinogenesis
2010
Participants
Input
miR-181C RISC [cytosol]
(Homo sapiens)
NOTCH4 mRNA [cytosol]
(Homo sapiens)
Output
NOTCH4 mRNA:miR-181C RISC [cytosol]
(Homo sapiens)
Participates
as an event of
Pre-NOTCH Transcription and Translation (Homo sapiens)
Event Information
Go Biological Process
negative regulation of gene expression (0010629)
Authored
Orlic-Milacic, M (2011-11-14)
Egan, SE (2011-11-14)
Reviewed
Haw, R (2012-02-06)
Created
Orlic-Milacic, M (2011-11-02)
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