MIR200B/C microRNAs bind NOTCH1 mRNA

Stable Identifier
R-HSA-1912363
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Translation of NOTCH1 mRNA is inhibited by microRNAs miR-200B and miR-200C, which bind to the 3'UTR of NOTCH1 mRNA. Levels of miR-200B and miR-200C are decreased in pancreatic cancer cells with an EMT (epithelial to mesenchymal transition) phenotype, and the EMT phenotype is reversed by exogenous overexpression of miR-200B/C microRNAs, suggesting that miR-200B and mir-200C may be acting as tumor suppressors.

Literature References
PubMed ID Title Journal Year
20805998 Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

Kong, D, Banerjee, S, Ahmad, A, Sethi, S, Sarkar, FH, Wang, Z, Li, Y

PLoS One 2010
Participants
Participant Of
Authored
Reviewed
Created