MIR200B/C microRNAs bind NOTCH1 mRNA

Stable Identifier
R-HSA-1912363
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MIR200B/C microRNAs bind NOTCH1 mRNA
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Translation of NOTCH1 mRNA is inhibited by microRNAs miR-200B and miR-200C, which bind to the 3'UTR of NOTCH1 mRNA. Levels of miR-200B and miR-200C are decreased in pancreatic cancer cells with an EMT (epithelial to mesenchymal transition) phenotype, and the EMT phenotype is reversed by exogenous overexpression of miR-200B/C microRNAs, suggesting that miR-200B and mir-200C may be acting as tumor suppressors.
Literature References
PubMed ID Title Journal Year
20805998 Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells

Li, Y, Kong, D, Sarkar, FH, Sethi, S, Wang, Z, Banerjee, S, Ahmad, A

PLoS One 2010
Participants
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Output
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as an event of
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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