Galactosylation of Pre-NOTCH

Stable Identifier
R-HSA-1912352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Galactosylation of Pre-NOTCH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Beta-1,4-galactosyltransferase 1 (B4GALT1) is a Golgi membrane enzyme responsible for galactosylation of N-acetylglucosaminyl group added by fringe enzymes to O-linked fucosyl residues on NOTCH. This results in formation of trisaccharide chains on NOTCH (Gal-beta1,4-GlcNAc-beta1,3-fucitol), and is a necessary step for fringe-mediated modulation of NOTCH signaling.
Literature References
PubMed ID Title Journal Year
11707585 Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1

Chen, J, Moloney, DJ, Stanley, P

Proc Natl Acad Sci U S A 2001
10935626 Fringe is a glycosyltransferase that modifies Notch

Moloney, DJ, Panin, VM, Johnston, SH, Chen, J, Shao, L, Wilson, R, Wang, Y, Stanley, P, Irvine, KD, Haltiwanger, RS, Vogt, TF

Nature 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1 homodimer [Golgi membrane]

Physical Entity
B4GALT1 homodimer [Golgi membrane] (Homo sapiens)
Activity
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity (GO:0003831)
Inferred From
Galactosylation of Pre-Notch (Cricetulus griseus)
Authored
Egan, SE  (2011-11-14)
Orlic-Milacic, M  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
Cite Us!