Galactosylation of Pre-NOTCH

Stable Identifier
R-HSA-1912352
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
ReviewStatus
5/5
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Galactosylation of Pre-NOTCH
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Beta-1,4-galactosyltransferase 1 (B4GALT1) is a Golgi membrane enzyme responsible for galactosylation of N-acetylglucosaminyl group added by fringe enzymes to O-linked fucosyl residues on NOTCH. This results in formation of trisaccharide chains on NOTCH (Gal-beta1,4-GlcNAc-beta1,3-fucitol), and is a necessary step for fringe-mediated modulation of NOTCH signaling.

Literature References
PubMed ID Title Journal Year
11707585 Fringe modulation of Jagged1-induced Notch signaling requires the action of beta 4galactosyltransferase-1

Chen, J, Stanley, P, Moloney, DJ

Proc Natl Acad Sci U S A 2001
10935626 Fringe is a glycosyltransferase that modifies Notch

Shao, L, Wang, Y, Johnston, SH, Irvine, KD, Stanley, P, Haltiwanger, RS, Moloney, DJ, Wilson, R, Chen, J, Vogt, TF, Panin, VM

Nature 2000
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Catalyst Activity

beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity of B4GALT1 homodimer [Golgi membrane]

Physical Entity
B4GALT1 homodimer [Golgi membrane] (Homo sapiens)
Activity
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity (GO:0003831)
Inferred From
Galactosylation of Pre-Notch (Cricetulus griseus)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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