Reactome | GJB3 [endoplasmic reticulum membrane]

GJB3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-190625

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Connexin 31

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Gap junction trafficking and regulation (Homo sapiens)
    - Gap junction trafficking (Homo sapiens)
      - Gap junction assembly (Homo sapiens)
        
        Connexin synthesis (generic) (Homo sapiens)
        
        Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)
        
        GJB3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75712 GJB3

Gene Names

GJB3, CX31

Chain

chain:1-270

Reference Genes

BioGPS Gene:2707 GJB3

COSMIC (genes):GJB3 GJB3

CTD Gene:2707 GJB3

dbSNP Gene:2707 GJB3

ENSEMBL:ENSG00000188910.8 GJB3

HGNC:4285 GJB3

KEGG Gene (Homo sapiens):2707 GJB3

Monarch:2707 GJB3

NCBI Gene:2707 GJB3

UCSC:O75712 GJB3

Reference Transcript

Other Identifiers

11725825_a_at

16662322

205490_PM_x_at

205490_x_at

205491_PM_s_at

205491_s_at

215243_PM_s_at

215243_s_at

2707

4054415

4054416

4054417

4054419

4054420

41076_at

7899932

A_23_P201854

A_24_P379233

GE54484

GE88103

GO:0001701

GO:0001890

GO:0005215

GO:0005243

GO:0005515

GO:0005737

GO:0005886

GO:0005911

GO:0005921

GO:0005922

GO:0007154

GO:0007267

GO:0007283

GO:0016020

GO:0022414

GO:0023052

GO:0030054

GO:0043226

GO:0043231

GO:0043588

GO:0048856

GO:0055085

GO:0070161

GO:0071300

HMNXSV003026534

Hs.98485.0.S1_3p_a_at

ILMN_1731525

ILMN_1789575

ILMN_2334531

PH_hs_0025026

PH_hs_0028561

TC01000450.hg

g13128959_3p_a_at

Participates

as a candidate of

Monomeric connexin protein [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Gjb3 [endoplasmic reticulum membrane] (Mus musculus)

Gjb3 [endoplasmic reticulum membrane] (Rattus norvegicus)

GJB3 [endoplasmic reticulum membrane] (Bos taurus)

GJB3 [endoplasmic reticulum membrane] (Sus scrofa)

gjb3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001005752.1, NP_076872.1

Guide to Pharmacology - Targets

720

OpenTargets

ENSG00000188910

HPA

ENSG00000188910-GJB3

GeneCards

O75712

Ensembl

ENSP00000362460, ENST00000373366, ENST00000373362, ENSP00000362464, ENSG00000188910

PRO

O75712

Pharos - Targets

O75712

Orphanet

16131

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:O43561-2 LAT	2	p-5Y-LAT-2 [plasma membrane] (R-HSA-2396597) LAT-2 [plasma membrane] (R-HSA-2396548)	0.556	3
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3