Connexin-interacting proteins appear to function in regulating gap junction formation and communication. ZO-1 has been shown to alter the membrane localization of Cx43 and plays a role in regulating Cx43-mediated gap junctional communication in osteoblastic cells (Laing et al. 2005). ZO-1 may function in the delivery of Cx43 from a lipid raft domain to gap junctional plaques, which may be an important regulatory step in gap junction formation.
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