Autocatalytic phosphorylation of FGFR2b

Stable Identifier
Reaction [transition]
Homo sapiens
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The intrinsic protein tyrosine kinase activity of the activated FGFR2b receptor leads to multiple phosphorylation events, creating a number of binding sites on its cytoplasmic tail for membrane bound docking proteins to gather intracellular signaling mediators. Two isoforms of FGFR2b generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets. Based on sequence alignment, FGFR2 contains all 8 of the cytoplasmic tyrosine residues identified in FGFR1.

Literature References
PubMed ID Title Journal Year
1697263 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors

Dionne, CA, Crumley, G, Bellot, F, Kaplow, JM, Searfoss, G, Ruta, M, Burgess, WH, Jaye, M, Schlessinger, J

EMBO J 1990
8622701 Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

Mohammadi, M, Dikic, I, Sorokin, A, Burgess, WH, Jaye, M, Schlessinger, J

Mol Cell Biol 1996
1379698 Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

Mohammadi, M, Dionne, CA, Li, W, Li, N, Spivak, T, Honegger, AM, Jaye, M, Schlessinger, J

Nature 1992
1656221 A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1

Mohammadi, M, Honegger, AM, Rotin, D, Fischer, R, Bellot, F, Li, W, Dionne, CA, Jaye, M, Rubinstein, M, Schlessinger, J

Mol Cell Biol 1991
11294897 Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation

Hart, KC, Robertson, SC, Donoghue, DJ

Mol Biol Cell 2001
Participant Of
Catalyst Activity
Catalyst Activity
protein tyrosine kinase activity of FGFR2b homodimer bound to FGF [plasma membrane]
Physical Entity
Orthologous Events
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