Reactome | FGFR2c binds to FGF

FGFR2c binds to FGF

Stable Identifier

R-HSA-190258

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - FGFR2 ligand binding and activation (Homo sapiens)
        
        FGFR2c ligand binding and activation (Homo sapiens)
        
        FGFR2c binds to FGF (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In this reaction, FGF receptor 2c in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2c generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets.

Literature References

PubMed ID	Title	Journal	Year
15863029	Structural basis for fibroblast growth factor receptor activation Olsen, SK, Mohammadi, M, Ibrahimi, OA	Cytokine Growth Factor Rev	2005
16597617	Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. Ornitz, DM, Umemori, H, Mohammadi, M, Olsen, SK, Ibrahimi, OA, Zhang, X	J Biol Chem	2006