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FGFR1b binds to FGF
Stable Identifier
R-HSA-190245
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
4/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1b ligand binding and activation (Homo sapiens)
FGFR1b binds to FGF (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. NCAM and other members of the CAM protein family directly or indirectly modulate this interaction in a variety of neural tissues. The details of this interaction in vivo have not been definitively established at the molecular level, but are thought to play a central role in the regulation of the development of these tissues. Also, TGFBR3 (beta-glycan) facilitates the binding of FGF2 with its receptor FGFR1 by binding with FGF2 itself and bringing more ligands into receptor proximity (Andres et al. 1992, Knelson et al. 2013).
Literature References
PubMed ID
Title
Journal
Year
16597617
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Ornitz, DM
,
Umemori, H
,
Mohammadi, M
,
Olsen, SK
,
Ibrahimi, OA
,
Zhang, X
J Biol Chem
2006
Participants
Input
x 2
FGFR1b [plasma membrane]
(Homo sapiens)
x 2
FGFR1b-binding FGFs [extracellular region]
(Homo sapiens)
HS [extracellular region]
Output
FGFR1b homodimer bound to FGF [plasma membrane]
(Homo sapiens)
Participates
as an event of
FGFR1b ligand binding and activation (Homo sapiens)
This event is regulated
Positively by
Regulator
FGF2:TGFBR3:GIPC1 [plasma membrane]
(Homo sapiens)
Requirements
Requirement by 'HS [extracellular region]'
Orthologous Events
FGFR1b binds to FGF (Bos taurus)
FGFR1b binds to FGF (Caenorhabditis elegans)
FGFR1b binds to FGF (Canis familiaris)
FGFR1b binds to FGF (Danio rerio)
FGFR1b binds to FGF (Drosophila melanogaster)
FGFR1b binds to FGF (Gallus gallus)
FGFR1b binds to FGF (Mus musculus)
FGFR1b binds to FGF (Rattus norvegicus)
FGFR1b binds to FGF (Sus scrofa)
FGFR1b binds to FGF (Xenopus tropicalis)
Authored
de Bono, B (2007-01-10)
Reviewed
Mohammadi, M (2007-02-07)
Created
de Bono, B (2006-12-18)
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