FGFR1b binds to FGF

Stable Identifier
R-HSA-190245
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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FGFR1b binds to FGF
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In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. NCAM and other members of the CAM protein family directly or indirectly modulate this interaction in a variety of neural tissues. The details of this interaction in vivo have not been definitively established at the molecular level, but are thought to play a central role in the regulation of the development of these tissues.

Literature References
PubMed ID Title Journal Year
16597617 Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

Zhang, X, Ibrahimi, OA, Olsen, SK, Umemori, H, Mohammadi, M, Ornitz, DM

J Biol Chem 2006
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Requirements
Orthologous Events
FGFR1b binds to FGF (Bos taurus)
FGFR1b binds to FGF (Caenorhabditis elegans)
FGFR1b binds to FGF (Canis familiaris)
FGFR1b binds to FGF (Danio rerio)
FGFR1b binds to FGF (Drosophila melanogaster)
FGFR1b binds to FGF (Gallus gallus)
FGFR1b binds to FGF (Mus musculus)
FGFR1b binds to FGF (Rattus norvegicus)
FGFR1b binds to FGF (Sus scrofa)
FGFR1b binds to FGF (Xenopus tropicalis)
Authored
de Bono, B  (2007-01-10)
Reviewed
Mohammadi, M  (2007-02-07)
Created
de Bono, B  (2006-12-18)