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About
What is Reactome ?
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Team
Scientific Advisory Board
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Release Calendar
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License Agreement
Privacy Notice
Disclaimer
Digital Preservation
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Contact us
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Table of Contents
DOIs
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Reactome Research Spotlight
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Klotho [extracellular region]
Stable Identifier
R-HSA-190207
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:FLRT [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1 binds FRS2 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1 binds FRS3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates FRS3 (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
SHC-mediated cascade:FGFR1 (Homo sapiens)
Activated FGFR1 binds SHC1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1 phosphorylates SHC1 (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1c and Klotho ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Participants
members
Membrane-bound Klotho homodimer [plasma membrane]
(Homo sapiens)
Secreted Klotho homodimer [extracellular region]
(Homo sapiens)
Participates
as a component of
Klotho homodimer [plasma membrane] (Homo sapiens)
Inferred To
Klotho [extracellular region]
(Bos taurus)
Klotho [extracellular region]
(Caenorhabditis elegans)
Klotho [extracellular region]
(Canis familiaris)
Klotho [extracellular region]
(Danio rerio)
Klotho [extracellular region]
(Drosophila melanogaster)
Klotho [extracellular region]
(Gallus gallus)
Klotho [extracellular region]
(Mus musculus)
Klotho [extracellular region]
(Rattus norvegicus)
Klotho [extracellular region]
(Sus scrofa)
Klotho [extracellular region]
(Xenopus tropicalis)
© 2024
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