Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
KL-1 [plasma membrane]
Stable Identifier
R-HSA-190198
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Klotho isoform 1, KLOT_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
PI3K/AKT Signaling in Cancer (Homo sapiens)
Constitutive Signaling by Aberrant PI3K in Cancer (Homo sapiens)
PI3K inhibitors block PI3K catalytic activity (Homo sapiens)
PI3K Inhibitors:PI3K [cytosol] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
PI3K mutants,Activator:PI3K [plasma membrane] (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
Negative regulation of the PI3K/AKT network (Homo sapiens)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activator:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR1 (Homo sapiens)
Downstream signaling of activated FGFR1 (Homo sapiens)
Activated FGFR1 binds FLRT1,2,3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:FLRT [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FRS-mediated FGFR1 signaling (Homo sapiens)
Activated FGFR1 binds FRS2 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1 binds FRS3 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates FRS3 (Homo sapiens)
Activated FGFR1:FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS bind to PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Homo sapiens)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS3 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
PI-3K cascade:FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Phospholipase C-mediated cascade: FGFR1 (Homo sapiens)
Activated FGFR1 binds PLCG1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates PLCG1 (Homo sapiens)
activated FGFR1:PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
p-4Y-PLCG1 dissociates from activated FGFR1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
SHC-mediated cascade:FGFR1 (Homo sapiens)
Activated FGFR1 binds SHC1 (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1 phosphorylates SHC1 (Homo sapiens)
Activated FGFR1:SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Homo sapiens)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-SHC1 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FGFR1 ligand binding and activation (Homo sapiens)
FGFR1c and Klotho ligand binding and activation (Homo sapiens)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
FGFR1c binds to Klotho-bound FGF23 (Homo sapiens)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Negative regulation of FGFR1 signaling (Homo sapiens)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2 (Homo sapiens)
Activated FGFR1:FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
CBL ubiquitinates FRS2 and FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR1:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR1 [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Homo sapiens)
IGF1R signaling cascade (Homo sapiens)
IRS-related events triggered by IGF1R (Homo sapiens)
IRS-mediated signalling (Homo sapiens)
PI3K Cascade (Homo sapiens)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Homo sapiens)
PI3K-containing complexes [cytosol] (Homo sapiens)
Activated FGFR bound to PI3K [cytosol] (Homo sapiens)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Homo sapiens)
Activated FGFR:p-FRS2 [plasma membrane] (Homo sapiens)
Activated FGFR [plasma membrane] (Homo sapiens)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Homo sapiens)
Klotho bound to FGF23 [plasma membrane] (Homo sapiens)
Klotho homodimer [plasma membrane] (Homo sapiens)
Klotho [extracellular region] (Homo sapiens)
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
KL-1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UEF7-1 KL
Gene Names
KL
Other Identifiers
11757777_s_at
16773919
205978_PM_at
205978_at
3484910
3484911
3484912
3484917
3484918
3484919
3484920
3484923
3484924
3484925
3484926
3484927
3484928
3484929
3484930
3484931
3484932
38304_r_at
7968556
9365
A_14_P115975
A_23_P503064
GE53120
GO:0003085
GO:0003824
GO:0004553
GO:0004566
GO:0005104
GO:0005179
GO:0005499
GO:0005576
GO:0005886
GO:0005975
GO:0006091
GO:0006112
GO:0008289
GO:0008340
GO:0008422
GO:0008543
GO:0014823
GO:0016020
GO:0016324
GO:0016787
GO:0016798
GO:0017134
GO:0030501
GO:0033280
GO:0042421
GO:0043226
GO:0048018
GO:0055074
GO:0070062
GO:0071774
GO:0090080
GO:0098772
GO:1990776
HMNXSV003026889
ILMN_2352077
PH_hs_0022828
TC13000113.hg
Z84483_at
g4758653_3p_at
Participates
as a component of
Membrane-bound Klotho homodimer [plasma membrane] (Homo sapiens)
Inferred To
Homologues of KL-1 [plasma membrane]
(Caenorhabditis elegans)
Kl [plasma membrane]
(Mus musculus)
Kl [plasma membrane]
(Rattus norvegicus)
KL [plasma membrane]
(Bos taurus)
KL [plasma membrane]
(Canis familiaris)
KL [plasma membrane]
(Sus scrofa)
Dmel\CG9701 [plasma membrane]
(Drosophila melanogaster)
KL-1 [plasma membrane]
(Gallus gallus)
klo-2 [plasma membrane]
(Caenorhabditis elegans)
kl [plasma membrane]
(Danio rerio)
kl [plasma membrane]
(Xenopus tropicalis)
klo-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_004786.2
Guide to Pharmacology - Targets
3146
ENSEMBL
ENST00000380099
,
ENSP00000369442
OpenTargets
ENSG00000133116
HPA
ENSG00000133116-KL
PRO
Q9UEF7
Pharos - Targets
Q9UEF7
Orphanet
KL
HMDB Protein
HMDBP07765
PDB
7YSU
,
7YSW
,
7YSH
,
5W21
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
