Activated TrkA receptor internalizes to endosomes

Stable Identifier
R-HSA-190065
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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TRKA at the plasma membrane typically results in rapid endocytosis and subsequent passage of the receptors through a network of endosomal compartments (Harrington et al, 2011; Wu et al, 2001).
Literature References
PubMed ID Title Journal Year
21816277 Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival

Philippidou, P, Zweifel, LS, Harrington, AW, Glebova, NO, St Hillaire, C, Ginty, DD, Halegoua, S

Cell 2011
11466412 Nerve growth factor activates persistent Rap1 signaling in endosomes

Mobley, WC, Lai, CF

J Neurosci 2001
Participants
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Orthologous Events
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