Activated TrkA receptor internalizes to endosomes

Stable Identifier
R-HSA-190065
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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TRKA at the plasma membrane typically results in rapid endocytosis and subsequent passage of the receptors through a network of endosomal compartments (Harrington et al, 2011; Wu et al, 2001).

Literature References
PubMed ID Title Journal Year
11466412 Nerve growth factor activates persistent Rap1 signaling in endosomes

Lai, CF, Mobley, WC

J Neurosci 2001
21816277 Recruitment of actin modifiers to TrkA endosomes governs retrograde NGF signaling and survival

Harrington, AW, St Hillaire, C, Zweifel, LS, Glebova, NO, Philippidou, P, Halegoua, S, Ginty, DD

Cell 2011
Participants
Participant Of
Orthologous Events
Created