Reactome | p-5Y-NTRK1-1 [endosome membrane]

p-5Y-NTRK1-1 [endosome membrane]

Stable Identifier

R-HSA-190064

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Phosphorylated TrkA-1 receptor, p-5Y-NTRK1 isoform 1

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External Reference Information

External Reference

UniProt:P04629-1 NTRK1

Gene Names

NTRK1, MTC, TRK, TRKA

Other Identifiers

11741674_a_at

16672186

1892_s_at

208605_PM_s_at

208605_s_at

2361762

2361765

2361767

2361768

2361769

2361770

2361771

2361773

2361774

2361775

2361776

2361777

2361778

2361779

2361781

2361782

2361783

2361784

2361785

2361787

2361789

2361790

36805_s_at

4914

7906244

A_14_P101526

A_14_P133584

A_23_P34804

A_24_P265506

GE57874

GO:0001934

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005004

GO:0005030

GO:0005166

GO:0005515

GO:0005524

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005770

GO:0005886

GO:0006355

GO:0006468

GO:0007169

GO:0007283

GO:0007399

GO:0007411

GO:0007611

GO:0007623

GO:0008285

GO:0009410

GO:0009986

GO:0010008

GO:0010465

GO:0010623

GO:0010976

GO:0012501

GO:0016020

GO:0016740

GO:0018108

GO:0019900

GO:0021553

GO:0022414

GO:0030154

GO:0030183

GO:0030424

GO:0030425

GO:0031175

GO:0031410

GO:0031667

GO:0031901

GO:0031902

GO:0032991

GO:0035094

GO:0038083

GO:0038179

GO:0038180

GO:0042490

GO:0042802

GO:0042803

GO:0043025

GO:0043066

GO:0043068

GO:0043121

GO:0043226

GO:0043235

GO:0043524

GO:0043547

GO:0046579

GO:0046777

GO:0048011

GO:0048013

GO:0048406

GO:0048485

GO:0048666

GO:0048678

GO:0048856

GO:0050877

GO:0050965

GO:0050966

GO:0051092

GO:0051402

GO:0051599

GO:0051602

GO:0051896

GO:0051897

GO:0051965

GO:0051968

GO:0055037

GO:0055038

GO:0060009

GO:0060089

GO:0060384

GO:0060385

GO:0061368

GO:0070374

GO:0071316

GO:0071363

GO:0140096

GO:1990090

HMNXSV003014598

ILMN_1731777

ILMN_1770307

ILMN_2326075

PH_hs_0019265

TC01001328.hg

g4585711_3p_a_at

Participates

as a component of

Activated TrkA receptor complex [endosome membrane] (Homo sapiens)

Inferred To

phospho-NTRK1 [endosome membrane] (Gallus gallus)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Bos taurus)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Canis familiaris)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Mus musculus)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Rattus norvegicus)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Sus scrofa)

phospho-p-5Y-NTRK1-1 [endosome membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 496

Coordinate

496

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 676

Coordinate

676

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 680

Coordinate

680

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 681

Coordinate

681

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 791

Coordinate

791

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002520.2, NP_001012331.1, NP_001007793.1

Guide to Pharmacology - Targets

1817

OpenTargets

ENSG00000198400

ENSEMBL

ENST00000368196, ENST00000524377, ENSG00000198400, ENSP00000357179, ENSP00000431418

ZINC - FDA approved

NTRK1_HUMAN

ZINC - Substances

NTRK1_HUMAN

ZINC - Biogenic

NTRK1_HUMAN

ZINC target

P04629

PRO

P04629

GlyGen

P04629

PDB

4YNE, 6D1Z, 7XAF, 6PL1, 4GT5, 4PMM, 6D22, 6J5L, 4CRP, 7VKN, 6NPT, 5JFW, 8J5W, 7VKM, 5JFV, 8J63, 1WWW, 5KMK, 6DKW, 5KMM, 6DKG, 6NSS, 6PMB, 2N90, 6PL3, 5KVT, 6PMC, 5JFS, 5KMJ, 8YTD, 4PMS, 6D1Y, 4YPS, 5WR7, 5I8A, 7XBI, 6NSP, 6D20, 1WWA, 1HE7, 1SHC, 4PMP, 5JFX, 4AOJ, 7VKO, 5KMN, 8J61, 5KML, 7N3T, 2IFG, 6DKI, 6DKB, 8J5X, 4F0I, 6IQN, 6PMA, 6PME, 6PL2, 5H3Q, 6PL4, 4PMT, 5KMI, 5KMO, 8YTE

ZINC - Investigational

NTRK1_HUMAN

HPA

ENSG00000198400-NTRK1

GeneCards

NTRK1

Pharos - Targets

P04629

Orphanet

NTRK1

ZINC - Predictions - Purchasable

NTRK1_HUMAN

HMDB Protein

HMDBP01503

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01138 NGF	7	NGF [extracellular region] (R-HSA-167034) NGF(19-241) [endoplasmic reticulum lumen] (R-HSA-187047) NGF(19-241) [Golgi lumen] (R-HSA-187036) NGF(1-241) [endoplasmic reticulum lumen] (R-HSA-187026) NGF [cytosol] (R-HSA-190059) NGF [Golgi lumen] (R-HSA-166515) NGF(19-241) [extracellular region] (R-HSA-187033)	0.683	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.624	4
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.624	4
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413) NTRK1 [plasma membrane] (R-HSA-3008784) NTRK1 [Golgi membrane] (R-HSA-3008805) p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810)	0.621	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.604	3
UniProt:P01138-PRO_0000019600 NGF			0.544	2
UniProt:Q8K4V6 Q8K4V6			0.524	2
UniProt:P05067-4 APP	2	APP [mitochondrial inner membrane] (R-HSA-9839060) APP (535-695) [cytosol] (R-HSA-9839084)	0.508	7
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.499	2
UniProt:Q13501 SQSTM1	7	SQSTM1 [cytosol] (R-HSA-193937) SQSTM1 [nucleoplasm] (R-HSA-210961) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967)	0.499	2
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.499	2
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.463	3
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.462	2