Reactome | FGF2(143-288) [extracellular region]

FGF2(143-288) [extracellular region]

Stable Identifier

R-HSA-189898

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

FGF2, Fibroblast growth factor-2, Heparin-binding growth factor 2, FGF2_HUMAN, Basic fibroblast growth factor, bFGF

Locations in the PathwayBrowser for interactor ChEBI:28304 HEPARIN

Expand all

External Reference Information

External Reference

UniProt:P09038 FGF2

Gene Names

FGF2, FGFB

Chain

propeptide:1-142, chain:143-288

Reference Genes

BioGPS Gene:2247 FGF2

COSMIC (genes):FGF2 FGF2

CTD Gene:2247 FGF2

dbSNP Gene:2247 FGF2

ENSEMBL:ENSG00000138685 FGF2

HGNC:3676 FGF2

KEGG:hsa:2247 FGF2

Monarch:2247 FGF2

NCBI Gene:2247 FGF2

OMIM:134920 FGF2

UCSC:P09038 FGF2

Reference Transcript

Other Identifiers

11725039_at

11725040_at

11725041_at

1593_at

16970404

1828_s_at

204421_PM_s_at

204421_s_at

204422_PM_s_at

204422_s_at

2247

2742110

2742111

2742112

2742113

2742114

2742121

2742125

2742126

2742127

2742128

2742129

41806_at

8097256

A_14_P107501

A_14_P108631

A_23_P218918

A_33_P3379886

A_33_P3419696

GE57510

GO:0001525

GO:0001649

GO:0001658

GO:0001759

GO:0001935

GO:0001938

GO:0002042

GO:0002052

GO:0005104

GO:0005125

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0006325

GO:0006351

GO:0006355

GO:0006366

GO:0006935

GO:0007165

GO:0007265

GO:0007399

GO:0007405

GO:0008083

GO:0008201

GO:0008283

GO:0008284

GO:0008285

GO:0008543

GO:0009792

GO:0009887

GO:0010001

GO:0010595

GO:0010628

GO:0010629

GO:0010764

GO:0014843

GO:0019956

GO:0021762

GO:0021930

GO:0021940

GO:0022008

GO:0030154

GO:0030214

GO:0030324

GO:0030334

GO:0038001

GO:0040037

GO:0042056

GO:0042060

GO:0042491

GO:0042660

GO:0042802

GO:0043406

GO:0043410

GO:0043491

GO:0043536

GO:0043537

GO:0043542

GO:0045471

GO:0045609

GO:0045669

GO:0045765

GO:0045766

GO:0045944

GO:0046668

GO:0048018

GO:0048149

GO:0048598

GO:0048661

GO:0048678

GO:0048856

GO:0048863

GO:0048864

GO:0048870

GO:0050673

GO:0050679

GO:0050918

GO:0051209

GO:0051726

GO:0051781

GO:0051897

GO:0055085

GO:0060045

GO:0060070

GO:0060128

GO:0060129

GO:0060563

GO:0060591

GO:0060644

GO:0060978

GO:0061045

GO:0062072

GO:0070371

GO:0070374

GO:0071260

GO:0072089

GO:0090049

GO:0090050

GO:0090263

GO:0090722

GO:0098772

GO:1901135

GO:1902748

GO:1902895

GO:1902913

GO:1903377

GO:1903587

GO:1903672

GO:1904567

GO:1904707

GO:1904977

GO:1905278

GO:1905330

GO:1905555

GO:1905564

GO:2000544

GO:2000546

GO:2000573

GO:2000647

GO:2000648

GO:2000738

GO:2001028

HMNXSV003036302

ILMN_1744693

ILMN_2105919

J04513_at

M27968_s_at

PH_hs_0028108

TC04000630.hg

TC04002187.hg

g182562_3p_s_at

g4503698_3p_s_at

Participates

as an input of

as a member of

as a component of

as a candidate of

FGFRL1-binding FGFs [extracellular region] (Homo sapiens)

as an output of

Expression of FGF2 (Homo sapiens)

This entity regulates

Positively

Inferred To

FGF2 [extracellular region] (Bos taurus)

FGF2 [extracellular region] (Gallus gallus)

FGF2 [extracellular region] (Sus scrofa)

let-756 [extracellular region] (Caenorhabditis elegans)

Fgf2 [extracellular region] (Mus musculus)

Fgf2 [extracellular region] (Rattus norvegicus)

fgf2 [extracellular region] (Danio rerio)

fgf2 [extracellular region] (Xenopus tropicalis)

FGF2(143-288) [extracellular region] (Canis familiaris)

Cross References

RefSeq

NP_001348594.1, NP_001997.5

OpenTargets

ENSG00000138685

ENSEMBL

ENSP00000477134, ENSP00000264498, ENST00000644866, ENSP00000494222, ENST00000608478, ENST00000264498, ENSG00000138685

HPA

ENSG00000138685-FGF2

GeneCards

FGF2

ZINC - Substances

FGF2_HUMAN

ZINC target

P09038

PRO

P09038

Pharos - Targets

P09038

ZINC - Predictions - Purchasable

FGF2_HUMAN

HMDB Protein

HMDBP02107

PDB

1BFG, 2FGF, 4FGF, 1BFF, 4OEF, 6L4O, 1BLD, 4OEE, 1BFB, 1CVS, 1BFC, 8OM6, 8HUE, 1BAS, 1BLA, 2M49, 1IIL, 1FQ9, 8HU7, 1II4, 4OEG, 5X1O, 1FGA, 2BFH, 1EV2

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.912	9
UniProt:P26022 PTX3	3	PTX3 [specific granule lumen] (R-HSA-6799620) PTX3 [extracellular region] (R-HSA-6806290) PTX3 [tertiary granule lumen] (R-HSA-6800932)	0.788	16
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) p-8Y-FGFR2 K660M [plasma membrane] (R-HSA-2033300) p-8Y-FGFR2 K660E [plasma membrane] (R-HSA-2033298) phosphorylated FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-2071957) p-8Y-FGFR2 W290C [plasma membrane] (R-HSA-2029875) p-8Y-FGFR2 S267P [plasma membrane] (R-HSA-2029879) p-8Y-FGFR2 [plasma membrane] (R-HSA-2029874) p-8Y-FGFR2 N549K [plasma membrane] (R-HSA-2033306)	0.779	5
UniProt:Q14512 FGFBP1	1	FGFBP1 [extracellular region] (R-HSA-5656040)	0.618	3
UniProt:P98066 TNFAIP6	3	TNFAIP6 [ficolin-1-rich granule lumen] (R-HSA-6803311) TNFAIP6 [extracellular region] (R-HSA-6803348) TNFAIP6 [tertiary granule lumen] (R-HSA-6803341)	0.611	3
UniProt:P21802-1 FGFR2	20	p-8Y-FGFR2c long [plasma membrane] (R-HSA-190416) FGFR2c long [plasma membrane] (R-HSA-189920) p-8Y-FGFR2c Y375C [plasma membrane] (R-HSA-2029861) p-8Y-FGFR2c S372C [plasma membrane] (R-HSA-2029865) p-8Y-FGFR2c W290G [plasma membrane] (R-HSA-2029862) p-8Y-FGFR2c A315T [plasma membrane] (R-HSA-2071940) p-8Y-FGFR2c A314D [plasma membrane] (R-HSA-2071946) p-8Y-FGFR2c A314S [plasma membrane] (R-HSA-2071944) p-8Y-FGFR2c A315S mutant [plasma membrane] (R-HSA-2071942) p-8Y-FGFR2c P253R [plasma membrane] (R-HSA-2011880) p-8Y-FGFR2c S252W [plasma membrane] (R-HSA-2011879) FGFR2c S372C [plasma membrane] (R-HSA-2029886) FGFR2c Y375C [plasma membrane] (R-HSA-2029881) FGFR2c W290G [plasma membrane] (R-HSA-2029883) FGFR2c A315T [plasma membrane] (R-HSA-1637889) FGFR2c A314D [plasma membrane] (R-HSA-1637888) FGFR2c A314S [plasma membrane] (R-HSA-2071928) FGFR2c A315S [plasma membrane] (R-HSA-2071931) FGFR2c P253R [plasma membrane] (R-HSA-1637916) FGFR2c S252W [plasma membrane] (R-HSA-2011852)	0.558	2
ChEBI:28304 HEPARIN			0.558	2
UniProt:P11362-7 FGFR1			0.544	2
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	2
UniProt:P16070 CD44	2	CD44 [plasma membrane] (R-HSA-1031688) CD44 [secretory granule membrane] (R-HSA-6804776)	0.527	2
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.527	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) SDC1 [Golgi lumen] (R-HSA-2054105) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314)	0.527	2

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