Reactome | FGFR2c short [plasma membrane]

FGFR2c short [plasma membrane]

Stable Identifier

R-HSA-189885

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Fibroblast growth factor receptor 2c short, FGFR2-5, Fibroblast growth factor receptor 2 precursor, FGR2_HUMAN, FGFR2 isoform 5

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by FGFR in disease (Homo sapiens)
    - Signaling by FGFR2 in disease (Homo sapiens)
      - FGFR2 mutant receptor activation (Homo sapiens)
        
        Signaling by FGFR2 IIIa TM (Homo sapiens)
        
        FGFR2IIIa TM binds ligand and full length receptors to inhibit signaling (Homo sapiens)
        
        FGFR2IIIa TM:FGF1,2:FGFR2b, FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2b, FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2c short [plasma membrane] (Homo sapiens)
        
        FGFR2b, FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2c short [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - FGFR2 ligand binding and activation (Homo sapiens)
        
        FGFR2c ligand binding and activation (Homo sapiens)
        
        Autocatalytic phosphorylation of FGFR2c (Homo sapiens)
        
        FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
        
        FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
        
        FGFR2c short homodimer [plasma membrane] (Homo sapiens)
        
        FGFR2c short [plasma membrane] (Homo sapiens)
        
        FGFR2c binds to FGF (Homo sapiens)
        
        FGFR2c [plasma membrane] (Homo sapiens)
        
        FGFR2c short [plasma membrane] (Homo sapiens)
        
        FGFR2c homodimer bound to FGF [plasma membrane] (Homo sapiens)
        
        FGFR2c short homodimer bound to FGF [plasma membrane] (Homo sapiens)
        
        FGFR2c short homodimer [plasma membrane] (Homo sapiens)
        
        FGFR2c short [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21802-5 FGFR2

Gene Names

FGFR2, BEK, KGFR, KSAM

Participates

as a member of

FGFR2c [plasma membrane] (Homo sapiens)

as a component of

FGFR2c short homodimer [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-8Y-FGFR2-5 [plasma membrane]

Inferred To

FGFR2c short [plasma membrane] (Bos taurus)

FGFR2c short [plasma membrane] (Caenorhabditis elegans)

FGFR2c short [plasma membrane] (Canis familiaris)

FGFR2c short [plasma membrane] (Danio rerio)

FGFR2c short [plasma membrane] (Drosophila melanogaster)

FGFR2c short [plasma membrane] (Gallus gallus)

FGFR2c short [plasma membrane] (Mus musculus)

FGFR2c short [plasma membrane] (Rattus norvegicus)

Homologues of FGFR2c short [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_075418.1, NP_001307583.1, NP_001138389.1, NP_001138388.1, NP_075259.4, NP_001138391.1, NP_001138387.1, NP_001138386.1, NP_001138390.1, NP_001138385.1, NP_001307587.1, NP_000132.3

Guide to Pharmacology - Targets

1809

ENSEMBL

ENST00000357555, ENSP00000358057, ENST00000360144, ENST00000682550, ENSP00000358056, ENST00000356226, ENST00000369060, ENST00000346997, ENSP00000358052, ENST00000359354, ENST00000358487, ENST00000457416, ENSP00000263451, ENSP00000352309, ENSP00000508257, ENST00000369061, ENSP00000350166, ENSP00000410294, ENSP00000351276, ENSP00000309878, ENST00000683211, ENSG00000066468, ENST00000351936, ENSP00000353262, ENST00000369056, ENSP00000348559, ENSP00000507633

OpenTargets

ENSG00000066468

ZINC - FDA approved

FGFR2_HUMAN

ZINC - Substances

FGFR2_HUMAN

ZINC - Biogenic

FGFR2_HUMAN

ZINC target

P21802

PRO

P21802

PDB

8STG, 1IIL, 2FDB, 1E0O, 3RI1, 1GJO, 6AGX, 1EV2, 8E1X, 3CU1, 2PVF, 6LVL, 7KIE, 3B2T, 2PZP, 4J99, 4J98, 1DJS, 4J96, 6V6Q, 2Q0B, 5UGL, 5UGX, 5EG3, 2PVY, 1NUN, 2PY3, 5UHN, 5UI0, 2PZ5, 3CLY, 4WV1, 3CAF, 8H75, 7KIA, 6LVK, 3EUU, 1WVZ, 8U1F, 2PZR, 3OJM, 3DAR, 2PSQ, 7OZY, 4J97, 1II4, 4J95, 8SWE, 3OJ2, 2PWL, 1OEC, 4J23

ZINC - Investigational

FGFR2_HUMAN

IntEnz

2.7.10.1

HPA

ENSG00000066468-FGFR2

GeneCards

FGFR2

Pharos - Targets

P21802

Orphanet

FGFR2

ZINC - Predictions - Purchasable

FGFR2_HUMAN

HMDB Protein

HMDBP01305

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09038 FGF2	1	FGF2(10-155) [extracellular region] (R-HSA-189898)	0.779	5
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.745	5
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.735	6
ChEBI:73280 SSR			0.683	8
UniProt:P05230 FGF1	1	FGF1 [extracellular region] (R-HSA-189856)	0.675	3
UniProt:P11362 FGFR1	9	FGFR1 [plasma membrane] (R-HSA-9756433) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) FGFR1 R576W [plasma membrane] (R-HSA-2011844) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.623	3
UniProt:O15520 FGF10	1	FGF10 [extracellular region] (R-HSA-189869)	0.571	2
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.528	3
UniProt:Q3MIR4 CC50B			0.527	2
UniProt:O60637 TSN3			0.527	2
UniProt:Q96LL9 DJC30			0.527	2
UniProt:Q6P047 CH074			0.527	2
UniProt:Q99732 LITAF			0.527	2
UniProt:Q8N7X8 SIGL1			0.527	2
UniProt:Q5T9A4 ATAD3B	3	ATAD3B [ficolin-1-rich granule membrane] (R-HSA-6801277) ATAD3B [plasma membrane] (R-HSA-6806518) ATAD3B [secretory granule membrane] (R-HSA-6801313)	0.527	2
UniProt:Q96HB5 CC120			0.527	2
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.527	2
UniProt:Q92551 IP6K1	2	IP6K1 [cytosol] (R-HSA-1604591) IP6K1 [nucleoplasm] (R-HSA-2023952)	0.527	2
UniProt:Q6P995 F171B			0.527	2
UniProt:Q92575 UBXN4			0.527	2
UniProt:Q96L94 SNX22			0.527	2
UniProt:Q96G30 MRAP2			0.527	2
UniProt:P55899 FCGRN			0.527	2
UniProt:Q5TF58 IFFO2			0.527	2
UniProt:P01033 TIMP1	4	p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691) TIMP1 [extracellular region] (R-HSA-349743) TIMP1 [platelet alpha granule lumen] (R-HSA-349745)	0.527	2
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536)	0.527	2
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.519	2
UniProt:Q9ULH0 KIDINS220	2	p-Y1095-KIDINS220 [cytosol] (R-HSA-169869) KIDINS220 [cytosol] (R-HSA-169880)	0.483	2
UniProt:Q9UBH6 S53A1			0.483	2
UniProt:Q86VI4 LAP4B			0.463	2

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