Reactome | Mitochondrial dALA translocates to cytosol

Mitochondrial dALA translocates to cytosol

Stable Identifier

R-HSA-189456

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

5-aminolevulinate(in) = 5-aminolevulinate(out), ALA is transported from the mitochondrial matrix to the cytosol

ReviewStatus

5/5

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Mitochondrial dALA translocates to cytosol

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5-aminolevulinate (dALA) is transported from the mitochondrial matrix to the cytosol. While indirect studies suggest that activity of the ABCB10 transporter is correlated with dALA production (Bayeva et al. 2013), biochemical studies of the purified protein indicate that dALA is not a transported substrate (Qiu et al. 2015), leaving the transporter that mediates dALA export to the cytosol and the role of ABCB10 in heme biosynthesis unknown.

Literature References

PubMed ID	Title	Journal	Year
26053025	ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione Qiu, W, Liesa, M, Carpenter, EP, Shirihai, OS	PLoS ONE	2015
23720443	ATP-binding cassette B10 regulates early steps of heme synthesis Bayeva, M, Khechaduri, A, Wu, R, Burke, MA, Wasserstrom, JA, Singh, N, Liesa, M, Shirihai, OS, Langer, NB, Paw, BH, Ardehali, H	Circ. Res.	2013