Mitochondrial dALA translocates to cytosol

Stable Identifier
R-HSA-189456
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
5-aminolevulinate(in) = 5-aminolevulinate(out), ALA is transported from the mitochondrial matrix to the cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Mitochondrial dALA translocates to cytosol
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
5-aminolevulinate (dALA) is transported from the mitochondrial matrix to the cytosol. While indirect studies suggest that activity of the ABCB10 transporter is correlated with dALA production (Bayeva et al. 2013), biochemical studies of the purified protein indicate that dALA is not a transported substrate (Qiu et al. 2015), leaving the transporter that mediates dALA export to the cytosol and the role of ABCB10 in heme biosynthesis unknown.
Literature References
PubMed ID Title Journal Year
26053025 ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione

Shirihai, OS, Qiu, W, Carpenter, EP, Liesa, M

PLoS ONE 2015
23720443 ATP-binding cassette B10 regulates early steps of heme synthesis

Singh, N, Shirihai, OS, Paw, BH, Wu, R, Ardehali, H, Burke, MA, Langer, NB, Liesa, M, Bayeva, M, Khechaduri, A, Wasserstrom, JA

Circ. Res. 2013
Participants
Input
Output
Participates
as an event of
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
D'Eustachio, P  (2007-01-24)
Reviewed
Sassa, S  (2007-01-24)
Created
Jassal, B  (2006-11-20)
Cite Us!