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ALAS1 [mitochondrial matrix]
Stable Identifier
R-HSA-189438
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
5-aminolevulinate synthase, non-specific, HEM1_HUMAN, 5-aminolevulinate synthase, non-specific, mitochondrial
Locations in the PathwayBrowser for interactor UniProt:Q02821
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 [mitochondrial matrix] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ALAS1 (Homo sapiens)
ALAS1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13196 ALAS1
Gene Names
ALAS1, ALAS3, ALASH, OK/SW-cl.121
Chain
transit peptide:1-56, chain:57-640
Reference Genes
BioGPS Gene:211 ALAS1
COSMIC (genes):ALAS1 ALAS1
CTD Gene:211 ALAS1
dbSNP Gene:211 ALAS1
ENSEMBL:ENSG00000023330 ALAS1
ENSEMBL_homo_sapiens_GENE:ENSG00000023330.15 ALAS1
HGNC:396 ALAS1
KEGG Gene (Homo sapiens):211 ALAS1
Monarch:211 ALAS1
NCBI Gene:211 ALAS1
OMIM:125290 ALAS1
Reference Transcript
RefSeq:NM_001304443.1 ALAS1
RefSeq:NM_000688.5 ALAS1
RefSeq:NM_199166.2 ALAS1
RefSeq:NM_001304444.1 ALAS1
Other Identifiers
11719328_a_at
11719329_x_at
11733041_a_at
11750973_a_at
16941344
205633_PM_s_at
205633_s_at
211
2623526
2623527
2623529
2623530
2623532
2623535
2623537
2623538
2623539
2623540
2623542
2623543
2623545
2623546
2623547
2623551
2623552
2623553
37674_at
8080184
A_23_P57877
A_24_P191588
GE59815
GE60231
GO:0002376
GO:0003824
GO:0003870
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005743
GO:0005759
GO:0005829
GO:0006778
GO:0006782
GO:0006783
GO:0006784
GO:0006785
GO:0009058
GO:0016020
GO:0016740
GO:0016746
GO:0030154
GO:0030170
GO:0033014
GO:0042541
GO:0042802
GO:0043226
GO:0048034
GO:0048821
GO:0048856
GO:1903412
HMNXSV003050344
ILMN_1700047
ILMN_1728309
ILMN_2385647
PH_hs_0026670
PH_hs_0031344
TC03000329.hg
Y00451_s_at
g4502024_3p_a_at
Participates
as a component of
ALAS1:heme [mitochondrial matrix] (Homo sapiens)
as an output of
Expression of ALAS1 (Homo sapiens)
Other forms of this molecule
PXLP-ALAS1 [mitochondrial matrix]
Inferred To
Alas [mitochondrial matrix]
(Drosophila melanogaster)
alas1 [mitochondrial matrix]
(Xenopus tropicalis)
ALAS1 [mitochondrial matrix]
(Bos taurus)
ALAS1 [mitochondrial matrix]
(Canis familiaris)
ALAS1 [mitochondrial matrix]
(Mus musculus)
ALAS1 [mitochondrial matrix]
(Rattus norvegicus)
ALAS1 [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_001291372.1
,
NP_954635.1
,
NP_000679.1
,
NP_001291373.1
OpenTargets
ENSG00000023330
IntEnz
2.3.1.37
HPA
ENSG00000023330-ALAS1
GeneCards
P13196
Ensembl
ENSP00000378416
,
ENSG00000023330
,
ENST00000469224
,
ENSP00000417719
,
ENST00000310271
,
ENST00000394965
,
ENST00000484952
,
ENSP00000418779
,
ENSP00000309259
PRO
P13196
Pharos - Targets
P13196
Orphanet
27149
HMDB Protein
HMDBP00022
Interactors (62)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8WTR2 DUS19
0.871
9
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.781
9
UniProt:P63313 TYB10
0.718
6
UniProt:Q17RB8 LONRF1
1
LONRF1 [cytosol]
(R-HSA-8850905)
0.718
6
UniProt:Q17RB0 RTL8B
0.718
6
UniProt:Q8TBZ8 ZNF564
1
ZNF564 [nucleoplasm]
(R-HSA-1973885)
0.718
6
UniProt:Q8WW24 TEKT4
0.718
6
UniProt:Q9Y473 ZNF175
1
ZNF175 [nucleoplasm]
(R-HSA-975022)
0.718
6
UniProt:O60437 PPL
2
PPL [cytosol]
(R-HSA-6810850)
PPL [cornified envelope]
(R-HSA-8847709)
0.718
6
UniProt:Q6PF15 KLH35
0.675
4
UniProt:Q9Y2S7 PDIP2
0.666
4
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.666
4
UniProt:Q96L91 EP400
1
EP400 [nucleoplasm]
(R-HSA-3321987)
0.666
4
UniProt:Q9BVS5 TRMT61B
1
TRMT61B [mitochondrial matrix]
(R-HSA-6787512)
0.615
3
IntAct:EBI-10198008 7120
0.556
3
IntAct:EBI-10197995 7116
0.556
3
UniProt:Q5W5X9 TTC23
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:Q7Z614 SNX20
0.556
3
UniProt:P53829 CAF40
0.556
3
UniProt:A8MXD5 GRXCR1
1
GRXCR1 [cytosol]
(R-HSA-9663063)
0.556
3
UniProt:Q9NWW7 CB042
0.556
3
UniProt:C9JCN9 HSBPL
0.556
3
UniProt:Q9UMF0 ICAM5
1
ICAM5 [plasma membrane]
(R-HSA-197684)
0.556
3
UniProt:P08579 SNRPB2
1
SNRPB2 [nucleoplasm]
(R-HSA-71960)
0.556
3
UniProt:O75564-2 O755642
0.556
3
UniProt:P48837
1
NUP57 [nuclear envelope]
(R-SCE-157724)
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:Q9NVN8 GNL3L
0.556
3
UniProt:P40123 CAP2
1
CAP2 [cytosol]
(R-HSA-428863)
0.556
3
UniProt:Q68DK2-5 ZFYVE26
0.556
3
UniProt:P32902
1
MRP4 [mitochondrial matrix]
(R-SCE-9839682)
0.556
3
UniProt:Q5TAP6 UTP14C
1
UTP14C [nucleoplasm]
(R-HSA-8867818)
0.556
3
UniProt:O14645 IDLC
0.556
3
UniProt:Q6P444 MTFR2
0.556
5
IntAct:EBI-10192162 7115
0.556
3
UniProt:Q96CD0 FBXL8
1
FBXL8 [cytosol]
(R-HSA-8850912)
0.556
3
UniProt:Q02821
2
SRP1 [cytosol]
(R-SCE-180612)
SRP1 [cytosol]
(R-SCE-9734672)
0.556
3
UniProt:Q9Y2K6 USP20
1
USP20 [cytosol]
(R-HSA-5696946)
0.556
3
UniProt:O43516 WIPF1
1
WIPF1 [cytosol]
(R-HSA-201874)
0.556
3
UniProt:Q8TCT0 CERK
1
CERK [plasma membrane]
(R-HSA-1631584)
0.556
3
UniProt:Q765P7 MTSS2
0.556
3
IntAct:EBI-10198019 84460
0.556
3
UniProt:O75128 COBL
0.556
3
UniProt:Q4VC05 BCL7A
1
BCL7A [nucleoplasm]
(R-HSA-9727449)
0.556
3
UniProt:Q9H788 SH24A
0.556
3
UniProt:Q96CN5 LRC45
0.556
3
UniProt:A0A0A0MR80 A0A0A0MR80
0.556
3
IntAct:EBI-22620261 CCSB ORF ID
0.556
3
UniProt:Q0P5Q0 Q0P5Q0
0.556
3
UniProt:P40099
1
MTHFS [cytosol]
(R-SCE-6801331)
0.556
3
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.556
3
UniProt:Q8IYW5 RNF168
2
monoSUMO1-RNF168 [nucleoplasm]
(R-HSA-4551750)
RNF168 [nucleoplasm]
(R-HSA-4551605)
0.556
3
UniProt:Q9NZQ9 TMOD4
1
TMOD4 [cytosol]
(R-HSA-5694030)
0.527
2
UniProt:Q5BKU9 OXLD1
0.527
2
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
4
UniProt:Q5T1C6 THEM4
3
THEM4 [mitochondrial matrix]
(R-HSA-162408)
THEM4 [cytosol]
(R-HSA-6809345)
THEM4 [plasma membrane]
(R-HSA-199437)
0.527
2
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.527
2
UniProt:Q8IVS2 MCAT
1
MCAT [mitochondrial matrix]
(R-HSA-8933305)
0.527
3
UniProt:Q16822 PCK2
1
PCK2 [mitochondrial matrix]
(R-HSA-372815)
0.527
2
UniProt:P14324 FDPS
1
FDPS [cytosol]
(R-HSA-981566)
0.527
2
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