Reactome | trehalose + H2O => 2 D-glucose

trehalose + H2O => 2 D-glucose

Stable Identifier

R-HSA-188985

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Digestion of trehalose to yield glucose

ReviewStatus

5/5

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Extracellular trehalose, a disaccharide, is cleaved by trehalase associated with the plasma membrane to yield two molecules of glucose. Trehalase has been purified to homogeneity from rabbit intestine and shown to be a monomer attached to the plasma membrane by a GPI anchor (Galand 1984; Ruf et al. 1990). A human cDNA encoding a closely homologous protein has been cloned and its protein product has been shown to have trehalase activity in vitro (Ishihara et al. 1997). The human enzyme has not been characterized further, and so both the posttranslational modifications of the human enzyme and its activity in vivo have been inferred from the properties of the well studied rabbit enzyme.

Trehalase deficiency has been described in two isolated cases in Europe (Bergoz 1971; Madzarovovà-Nohejlova 1973) and at high frequency in a population of Greenland natives (Gudmand-Hoyer et al. 1988) but molecular defects responsible for the deficiency have not yet been described so it is not annotated in Reactome.

Literature References

PubMed ID	Title	Journal	Year
5104075	Trehalose malabsorption causing intolerance to mushrooms. Report of a probable case Bergoz, R	Gastroenterology	1971
1697585	Rabbit small intestinal trehalase. Purification, cDNA cloning, expression, and verification of glycosylphosphatidylinositol anchoring. von Kieckebusch, A, Mantei, N, Semenza, G, James, P, Ruf, J, Galand, G, Wacker, H, Maffia, M, Seiler, P	J Biol Chem	1990
9427547	Molecular cloning, sequencing and expression of cDNA encoding human trehalase Kobayashi, Y, Ishihara, R, Kino, M, Sasai-Takedatsu, M, Tokunaga, R, Taketani, S	Gene	1997
6466686	Purification and characterization of kidney and intestinal brush-border membrane trehalases from the rabbit Galand, G	Biochim Biophys Acta	1984
4737205	Trehalase deficiency in a family Madzarovovà-Nohejlova, J	Gastroenterology	1973
3227291	Trehalase deficiency in Greenland Gudmand-Høyer, E, Skovbjerg, H, Madsen, PR, Fenger, HJ, Kern-Hansen, P	Scand. J. Gastroenterol.	1988