Assembly of M2 tetramers

Stable Identifier
R-HSA-188544
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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General
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The M2 from influenza A virus is a 97-residue protein with a single transmembrane helix that associates to form a tetramer in the endoplasmic reticulum (Salom et al, 2000). A 15-20-residue segment C-terminal to the membrane-spanning region has been postulated to aid in the stabilization of the tetrameric assembly (Kochendoerfer et al 1999).

Literature References
PubMed ID Title Journal Year
11087364 pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus

Salom, D, Hill, BR, Lear, JD, DeGrado, WF

Biochemistry 2000
Participants
Participant Of
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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