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Assembly of M2 tetramers
Stable Identifier
R-HSA-188544
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Influenza Infection (Homo sapiens)
Virus Assembly and Release (Homo sapiens)
Assembly of Viral Components at the Budding Site (Homo sapiens)
Assembly of M2 tetramers (Homo sapiens)
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The M2 from influenza A virus is a 97-residue protein with a single transmembrane helix that associates to form a tetramer in the endoplasmic reticulum (Salom et al, 2000). A 15-20-residue segment C-terminal to the membrane-spanning region has been postulated to aid in the stabilization of the tetrameric assembly (Kochendoerfer et al 1999).
Literature References
PubMed ID
Title
Journal
Year
11087364
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus
DeGrado, WF
,
Salom, D
,
Hill, BR
,
Lear, JD
Biochemistry
2000
Participants
Input
x 4
M2 [endoplasmic reticulum membrane]
(Influenza A virus)
Output
M2 Tetramer [endoplasmic reticulum membrane]
(Influenza A virus)
Participates
as an event of
Assembly of Viral Components at the Budding Site (Homo sapiens)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
Gillespie, ME (2006-10-17)
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