Rab5-mediated recruitment of class III PI3K to TLR9

Stable Identifier
R-HSA-188002
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TLR9 signaling has the uncommon property of triggering PI3K-mediated cascades via Rab5.
Literature References
PubMed ID Title Journal Year
14751759 Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9

Klinman, DM, Gursel, M, Ishii, KJ, Suzuki, K, Gursel, I, Takeshita, F

Semin Immunol 2004
17878374 TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway

Lebranchu, Y, François, S, Hoarau, C, Gougerot-Pocidalo, MA, El Benna, J, Dang, PM, Lescanne, E, Grandchamp, B, Gérard, B, Elbim, C, Lacapère, JJ, Henry, D

J. Immunol. 2007
Participants
Participates
This event is regulated
Orthologous Events
Created
Cite Us!