Reactome | Inactivation of Cyclin A:Cdk2 complexes by p27/p21

Inactivation of Cyclin A:Cdk2 complexes by p27/p21

Stable Identifier

R-HSA-187934

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest (Homo sapiens)
        
        Inactivation of Cyclin A:Cdk2 complexes by p27/p21 (Homo sapiens)

General

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Inactivation of Cyclin A:Cdk2 complexes by p27/p21

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During G1, the activity of cyclin-dependent kinases (CDKs) is controlled by the CDK inhibitors (CKIs) CDKN1A (p21) and CDKN1B (p27), thereby preventing premature entry into S phase (Guardavaccaro and Pagano, 2006).

Literature References

PubMed ID	Title	Journal	Year
10323868	Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation Eytan, E, Draetta, GF, Hershko, A, Montagnoli, A, Pagano, M, Carrano, AC, Fiore, F	Genes Dev	1999
8242751	The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Keyomarsi, K, Elledge, SJ, Adami, GR, Wei, N, Harper, JW	Cell	1993