RIT/RIN are activated

Stable Identifier
R-HSA-187746
Type
Reaction
Species
Homo sapiens
Compartment
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RIT and RIN are activated by neurotrophins through unknown exchange factors. Activation reaches a maximal level between 5 and 15 min after NGF stimulation and remains elevated for at least 2 h. RIN, which is neuron-specific, might function as a component of a neuron specific B-RAF signalosome complex, in which RIN provides spatial and/or substrate specificity to the B-RAF-MEK kinase cascade to direct stimulation of p38 signaling.

Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of Guanine nucleotide exchange factor [cytosol]

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