RIT/RIN-GTP binds B-RAF

Stable Identifier
R-HSA-187698
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
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RIT/RIN-GTP binds B-RAF
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Once activated by RIT or RIN, B-RAF activates, through MEK, the p38 MAP kinase. Whereas RIN appears to activate p38 (specifically the p38-alpha isoform) but not the ERKs, RIN was described to activate ERK1/ ERK2 as well, although to a much lower extent than p38. RIN signaling gives rise to sustained activation of p38 MAP kinase.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rit-GTP binds Raf (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-09-21)