ADCYAP1(2-742) binds ADCYAP1R1 and NTRK1,2

Stable Identifier
R-HSA-187678
Type
Reaction [binding]
Species
Homo sapiens
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Neurotrophins regulate neuronal cell survival and synaptic plasticity through activation of nerve growth factor receptor tyrosine kinases (NTRKs). Pituitary adenylate cyclase-activating polypeptide (ADCYAP1), a neuromodulator acting through type 1 PACAP receptors (ADCYAP1R1), can transactivate NTRKs in the absence of neurotrophins (Jeanneteau & Chao 2006). The mechanism of this activation is not fully understood. First, ADCYAP1 binds ADCYAP1R1 and NTRK1 and NTRK2.

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