Ubiquitination of phospho-p27/p21

Stable Identifier
R-HSA-187575
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Ubiquitination of phospho-p27/p21
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Once in tight contact with the SCF (Skp2):Cks1 complex, phosphorylated p27/p21 is ubiquitinated.
Literature References
PubMed ID Title Journal Year
11231585 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

Ganoth, D, Bornstein, G, Ko, TK, Larsen, B, Tyers, M, Pagano, M, Hershko, A

Nat Cell Biol 2001
Participants
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Output
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as an event of
Catalyst Activity

ubiquitin-protein transferase activity of Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm]

Physical Entity
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
Ubiquitination of phospho-p27/p21 (Bos taurus)
Ubiquitination of phospho-p27/p21 (Caenorhabditis elegans)
Ubiquitination of phospho-p27/p21 (Canis familiaris)
Ubiquitination of phospho-p27/p21 (Danio rerio)
Ubiquitination of phospho-p27/p21 (Drosophila melanogaster)
Ubiquitination of phospho-p27/p21 (Gallus gallus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
Ubiquitination of phospho-p27/p21 (Rattus norvegicus)
Ubiquitination of phospho-p27/p21 (Sus scrofa)
Authored
Pagano, M  (2006-09-19)
Reviewed
Coqueret, O  (2006-10-06)
Created
Matthews, L  (2006-09-20)
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