Reactome | CKS1B [nucleoplasm]

CKS1B [nucleoplasm]

Stable Identifier

R-HSA-187533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cks1

Locations in the PathwayBrowser for interactor UniProt:Q12834 CDC20

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External Reference Information

External Reference

UniProt:P61024 CKS1B

Gene Names

CKS1B, CKS1, PNAS-143, PNAS-16

Chain

initiator methionine:, chain:2-79

Reference Genes

BioGPS Gene:1163 CKS1B

COSMIC (genes):CKS1B CKS1B

CTD Gene:1163 CKS1B

dbSNP Gene:1163 CKS1B

ENSEMBL:ENSG00000173207 CKS1B

ENSEMBL_homo_sapiens_GENE:ENSG00000173207.13 CKS1B

HGNC:19083 CKS1B

KEGG Gene (Homo sapiens):1163 CKS1B

Monarch:1163 CKS1B

NCBI Gene:1163 CKS1B

OMIM:116900 CKS1B

Reference Transcript

RefSeq:NM_001826.2 CKS1B

Other Identifiers

1163

11716092_x_at

11754031_s_at

11758200_x_at

201897_PM_s_at

201897_s_at

2360453

2360454

2360460

2360462

2360463

2360464

2360465

2859242

2859243

3240804

37347_at

7905826

7926896

8112327

A_23_P45917

GE59801

GE86719

GO:0000278

GO:0000307

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006351

GO:0006355

GO:0007049

GO:0007346

GO:0016301

GO:0016310

GO:0016538

GO:0016740

GO:0019005

GO:0019901

GO:0042393

GO:0043130

GO:0043226

GO:0044772

GO:0048144

GO:0051301

GO:0061575

GO:0098772

HMNXSV003051939

ILMN_2041046

TC01004760.hg

X54941_at

g4502856_3p_a_at

Participates

as an input of

Association of Cks1 with SCF(Skp2) complex (Homo sapiens)

as a component of

CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Homo sapiens)

Inferred To

Cks1b [nucleoplasm] (Mus musculus)

Cks1b [nucleoplasm] (Rattus norvegicus)

cks1b [nucleoplasm] (Danio rerio)

cks1b [nucleoplasm] (Xenopus tropicalis)

CKS1B [nucleoplasm] (Bos taurus)

CKS1B [nucleoplasm] (Canis familiaris)

CKS1B [nucleoplasm] (Gallus gallus)

CKS1B [nucleoplasm] (Sus scrofa)

cks-1 [nucleoplasm] (Caenorhabditis elegans)

Cks30A [nucleoplasm] (Drosophila melanogaster)

cks1 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001817.1

OpenTargets

ENSG00000173207

HPA

ENSG00000173207-CKS1B

GeneCards

P61024

Ensembl

ENSP00000311083, ENSG00000173207, ENST00000308987

PRO

P61024

Pharos - Targets

P61024

PDB

7B5R, 4YC6, 7NJ0, 8BYA, 1DKT, 7B5M, 8OR4, 2AST, 7B5L, 1BUH, 2ASS, 8OR0, 8BYL, 1DKS

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.949	28
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.924	13
UniProt:Q13309 SKP2	3	SKP2 [cytosol] (R-HSA-975495) PolyUb-SKP2 [nucleoplasm] (R-HSA-9687073) SKP2 [nucleoplasm] (R-HSA-975554)	0.858	9
UniProt:Q00526 CDK3			0.8	7
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.8	5
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.784	7
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.781	7
UniProt:P0CI25 TRI49			0.742	5
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.725	6
UniProt:Q9UH03 SEPT3			0.718	6
UniProt:P50221 MEOX1			0.718	6
UniProt:Q9HAT0 ROPN1	1	ROPN1 [cytosol] (R-HSA-5667048)	0.718	6
UniProt:Q03989 ARI5A			0.696	5
UniProt:A6NLX3 SPDE4			0.666	6
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.643	5
UniProt:Q99640 PKMYT1	3	PKMYT1 [cytosol] (R-HSA-157457) p-PKMYT1 [nucleoplasm] (R-HSA-162650) PKMYT1 [nucleoplasm] (R-HSA-74386)	0.643	3
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.643	4
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.643	4
UniProt:P11440 Cdk1	11	phospho-p-T161-CDK1 [nucleoplasm] (R-MMU-170066) phospho-p-T14,Y15,T161-CDK1 [nucleoplasm] (R-MMU-170074) phospho-p-T161-CDK1 [cytosol] (R-MMU-157415) phospho-p-T14,Y15,T161-CDK1 [cytosol] (R-MMU-170071) CDK1 [cytosol] (R-MMU-170075) phospho-p-T14-CDK1 [cytosol] (R-MMU-170064) phospho-p-T14-CDK1 [nucleoplasm] (R-MMU-170045) Cdk1 [nucleoplasm] (R-MMU-1362302) phospho-p-T14,T161-CDK1 [nucleoplasm] (R-MMU-170078) phospho-p-Y4-CDK1 [cytosol] (R-MMU-9836187) CDK1 [endoplasmic reticulum membrane] (R-MMU-264424)	0.623	4
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:Q9UPY6-2 WASF3			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	3
UniProt:P0CI26 TR49C			0.556	3
UniProt:P15884-3 TCF4			0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:Q9UBR4-2 LHX3			0.556	3
UniProt:Q9UHV2 SRTD1			0.556	3
UniProt:Q13422 IKZF1			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:Q8NA61-2 CBY2			0.556	3
UniProt:Q86YW9 MD12L			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q96C00 ZBTB9			0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q5HYN5 CT451			0.556	3
UniProt:Q14142 TRIM14	1	TRIM14 [cytosol] (R-HSA-5624345)	0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q14140 SRTD2			0.556	3
UniProt:G2XKQ0 SUMO5			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q96KQ4 PPP1R13B	1	PPP1R13B [nucleoplasm] (R-HSA-6799775)	0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q99081-3 TCF12			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9UHG0 DCDC2			0.556	3
UniProt:O14627 CDX4			0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
UniProt:Q13285 NR5A1	3	NR5A1 [nucleoplasm] (R-HSA-452955) polySUMO2-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546383) monoSUMO1-K119,K194-NR5A1 [nucleoplasm] (R-HSA-4546382)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.527	2
UniProt:Q9H5V7 IKZF5			0.527	2
UniProt:O96020 CCNE2	3	Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [cytosol] (R-HSA-157452) CCNE2 [nucleoplasm] (R-HSA-68367)	0.527	2
UniProt:P33552 CKS2			0.527	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.527	3
UniProt:Q12834 CDC20	3	CDC20 [cytosol] (R-HSA-141412) CDC20 [nucleoplasm] (R-HSA-174112) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.527	3
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.527	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.527	2
UniProt:O75496 GMNN	2	GMNN [nucleoplasm] (R-HSA-113554) PolyUb-GMNN [nucleoplasm] (R-HSA-68585)	0.527	2
UniProt:O95067 CCNB2	1	CCNB2 [cytosol] (R-HSA-68897)	0.527	2

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