Reactome | BDNF(1-247) [endoplasmic reticulum lumen]

BDNF(1-247) [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-187041

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

BDNF pre-pro-precursor

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P23560 BDNF

Gene Names

BDNF

Chain

signal peptide:1-18, chain:19-247, propeptide:19-128, chain:129-247

Reference Genes

BioGPS Gene:627 BDNF

COSMIC (genes):BDNF BDNF

CTD Gene:627 BDNF

dbSNP Gene:627 BDNF

ENSEMBL:ENSG00000176697 BDNF

ENSEMBL_homo_sapiens_GENE:ENSG00000176697.20 BDNF

HGNC:1033 BDNF

KEGG Gene (Homo sapiens):627 BDNF

Monarch:627 BDNF

NCBI Gene:627 BDNF

OMIM:113505 BDNF

UCSC:P23560 BDNF

Reference Transcript

Other Identifiers

1088_at

11733750_a_at

11733751_s_at

11734642_a_at

11735902_a_at

11753244_a_at

206382_PM_s_at

206382_s_at

239367_PM_at

239367_at

3367232

3367233

3367234

3367235

3367236

3367237

3367238

3367239

3367240

3367241

3367242

3367243

3367244

3367245

3367246

3367247

3367248

3367249

3367250

3367251

3367253

3367254

3367255

3367262

3367263

3367264

3367265

3367266

3367267

3367269

3367270

3367271

3367272

3367273

3367274

40023_at

627

7947230

82966_at

A_23_P127891

A_32_P7316

GE81060

GO:0005102

GO:0005163

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005783

GO:0005788

GO:0007165

GO:0007169

GO:0007399

GO:0007411

GO:0007416

GO:0007422

GO:0007613

GO:0008021

GO:0008083

GO:0010832

GO:0010976

GO:0012501

GO:0021675

GO:0023052

GO:0030154

GO:0030424

GO:0030425

GO:0031410

GO:0031547

GO:0031550

GO:0033138

GO:0034330

GO:0036211

GO:0038180

GO:0043226

GO:0043524

GO:0045664

GO:0048018

GO:0048471

GO:0048668

GO:0048672

GO:0048812

GO:0048856

GO:0050804

GO:0050877

GO:0051965

GO:0098772

GO:1900122

GO:2000008

GO:2001234

HMNXSV003022207

Hs.146442.0.A1_3p_at

ILMN_1706644

ILMN_1712712

ILMN_1719820

ILMN_1751276

ILMN_1761910

ILMN_1793988

M61176_at

PH_hs_0026545

PH_hs_0026546

PH_hs_0028454

TC11003090.hg

g4502392_3p_a_at

Participates

as an output of

BDNF gene expression is stimulated by NPAS4:ARNT2 (Homo sapiens)

Other forms of this molecule

BDNF [extracellular region]

Cross References

RefSeq

NP_001137281.1, NP_001137279.1, NP_001137282.1, NP_001137288.1, NP_001700.2, NP_001137278.1, NP_001137283.1, NP_001137277.1, NP_001137284.1, NP_733928.1, NP_733931.1, NP_001137280.1, NP_733930.1, NP_733929.1, NP_001137285.1, XP_011518582.1, NP_733927.1, NP_001137286.1

OpenTargets

ENSG00000176697

HPA

ENSG00000176697-BDNF

GeneCards

P23560

Ensembl

ENST00000533131, ENST00000395983, ENST00000395981, ENST00000395986, ENSP00000435805, ENSP00000435564, ENSP00000432035, ENST00000530861, ENSP00000432376, ENST00000525528, ENSP00000320002, ENSP00000414303, ENST00000314915, ENST00000533246, ENSP00000379307, ENSP00000432727, ENSP00000379309, ENSP00000379302, ENST00000438929, ENSP00000379305, ENST00000532997, ENSP00000400502, ENSG00000176697, ENSP00000437138, ENST00000356660, ENST00000439476, ENSP00000389345, ENST00000418212, ENSP00000349084, ENST00000525950, ENST00000395978

PRO

P23560

Pharos - Targets

P23560

PDB

1BND, 1B8M

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34130 NTF4	1	NTF4 [extracellular region] (R-HSA-167063)	0.718	6
UniProt:P20783 NTF3	1	NTF3 [extracellular region] (R-HSA-167062)	0.59	3