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PDGFRA [plasma membrane]
Stable Identifier
R-HSA-186794
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:P04085 PDGFA
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Olaratumab binds PDGFRA (Homo sapiens)
PDGFRA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16234 PDGFRA
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Reference Genes
COSMIC (genes):PDGFRA PDGFRA
dbSNP Gene:5156 PDGFRA
ENSEMBL:ENSG00000134853 PDGFRA
Participates
as an input of
Olaratumab binds PDGFRA (Homo sapiens)
as a component of
PDGFRA:olaratumab [plasma membrane] (Homo sapiens)
Alpha-Beta receptor heterodimer [plasma membrane] (Homo sapiens)
Alpha receptor homodimer [plasma membrane] (Homo sapiens)
as a member of
PDGFRA, PDGFRB [plasma membrane] (Homo sapiens)
Other forms of this molecule
PDGFRA L629P [plasma membrane]
PDGFRA N659K [plasma membrane]
PDGFRA T674I [plasma membrane]
PDGFRA S601P [plasma membrane]
PDGFRA Y288C [endoplasmic reticulum membrane]
PDGFRA Y375_K455del [endoplasmic reticulum membrane]
p-11Y PDGFRA Y288C [endoplasmic reticulum membrane]
p-11Y-PDGFRA Y375_K455del [endoplasmic reticulum membrane]
PDGFRA D842_M844del [plasma membrane]
PDGFRA D842Y [plasma membrane]
PDGFRA D842V [plasma membrane]
PDGFRA I843_D846del [plasma membrane]
PDGFRA D842_H845del [plasma membrane]
PDGFRA D842del [plasma membrane]
PDGFRA D842_I843delinsV [plasma membrane]
PDGFRA D846Y [plasma membrane]
PDGFRA D843_845del [plasma membrane]
PDGFRA D842_D846del [plasma membrane]
PDGFRA N848K [plasma membrane]
PDGFRA Y849C [plasma membrane]
PDGFRA D843_844del [plasma membrane]
PDGFRA D846V [plasma membrane]
PDGFRA D842L [plasma membrane]
PDGFRA V561D [plasma membrane]
PDGFRA V561A [plasma membrane]
PDGFRA V536E [plasma membrane]
PDGFRA V536M [plasma membrane]
p-11Y PDGFRA D842V [plasma membrane]
p-11Y PDGFRA D846Y [plasma membrane]
p-11Y-PDGFRA [plasma membrane]
p-11Y PDGFRA V561A [plasma membrane]
p-11Y PDGFRA V561D [plasma membrane]
p-11Y PDGFRA V536M [plasma membrane]
p-11Y PDGFRA V536E [plasma membrane]
p-11Y PDGFRA D846V [plasma membrane]
p-11Y PDGFRA D842L dimer [plasma membrane]
p-11Y PDGFRA N848K [plasma membrane]
p-11Y PDGFRA D843_845del [plasma membrane]
p-10Y PDGFRA Y849C [plasma membrane]
p-11Y PDGFRA D842_D846del [plasma membrane]
p-11Y PDGFRA D842_H845del [plasma membrane]
p-11Y PDGFRA D842Y [plasma membrane]
p-11Y PDGFRA D843_846del [plasma membrane]
p-11Y-PDGFRA D842_I843delinsV [plasma membrane]
p-11Y PDGFRA D843_844del [plasma membrane]
p-11Y PDGFRA D842del [plasma membrane]
Inferred To
PDGFRA [plasma membrane]
(Bos taurus)
PDGFRA [plasma membrane]
(Caenorhabditis elegans)
PDGFRA [plasma membrane]
(Canis familiaris)
PDGFRA [plasma membrane]
(Danio rerio)
PDGFRA [plasma membrane]
(Drosophila melanogaster)
PDGFRA [plasma membrane]
(Gallus gallus)
PDGFRA [plasma membrane]
(Mus musculus)
PDGFRA [plasma membrane]
(Rattus norvegicus)
PDGFRA [plasma membrane]
(Sus scrofa)
PDGFRA [plasma membrane]
(Xenopus tropicalis)
kin-36 [plasma membrane]
(Caenorhabditis elegans)
Homologues of PDGFRA [plasma membrane]
(Caenorhabditis elegans)
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01127 PDGFB
8
PDGFB(82-241) [platelet alpha granule lumen]
(R-HSA-387075)
PDGFB(21-81) [platelet alpha granule lumen]
(R-HSA-184200)
PDGFB(191-241) [Golgi lumen]
(R-HSA-396945)
PDGFB(1-81) [Golgi lumen]
(R-HSA-389058)
PDGFB(1-241) [Golgi membrane]
(R-HSA-380740)
PDGFB(1-241) [endoplasmic reticulum lumen]
(R-HSA-381903)
PDGFB(82-241) [extracellular region]
(R-HSA-381904)
PDGFB (82-190) [extracellular region]
(R-HSA-184201)
0.733
11
UniProt:P09619 PDGFRB
3
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
0.706
5
UniProt:P04085 PDGFA
1
PDGFA [extracellular region]
(R-HSA-2426265)
0.691
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.683
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.671
4
UniProt:Q9NRA1 PDGFC
0.656
3
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.569
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.544
3
UniProt:Q8WVM8 SCFD1
1
SCFD1 [cytosol]
(R-HSA-5688147)
0.483
2
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