GBA3 hydrolyzes GlcCer (cytosol)

Stable Identifier
Reaction [transition]
Homo sapiens
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Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). However, the activity of GBA3 is relatively low and its significance in vivo is not clear (Dekker et al., 2011).
Literature References
PubMed ID Title Journal Year
12594539 Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

Jacob, R, Juge, N, Berrin, JG, Kroon, PA, Swallow, DM, Williamson, G, Naim, HY, Plumb, GW, Nemeth, K

Eur J Nutr 2003
11784319 Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides

Needs, P, Juge, N, Berrin, JG, Kroon, PA, Williamson, G, Puigserver, A, McLauchlan, WR

Eur J Biochem 2002
20728381 The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation

Narayan, RS, Wennekes, T, Boot, RG, Voorn-Brouwer, T, Speijer, D, Overkleeft, HS, Verhoek, M, Hollak, CE, Aerts, JM, Dekker, N

Blood Cells Mol Dis 2011
Catalyst Activity

glucosylceramidase activity of GBA3 [cytosol]

Orthologous Events
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