Reactome | GBA3 hydrolyzes GlcCer (cytosol)

GBA3 hydrolyzes GlcCer (cytosol)

Stable Identifier

R-HSA-1861789

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003). However, the activity of GBA3 is relatively low and its significance in vivo is not clear (Dekker et al., 2011).

Literature References

PubMed ID	Title	Journal	Year
12594539	Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans Nemeth, K, Plumb, GW, Berrin, JG, Juge, N, Jacob, R, Naim, HY, Williamson, G, Swallow, DM, Kroon, PA	Eur J Nutr	2003
11784319	Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides Berrin, JG, McLauchlan, WR, Needs, P, Williamson, G, Puigserver, A, Kroon, PA, Juge, N	Eur J Biochem	2002
20728381	The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation Dekker, N, Voorn-Brouwer, T, Verhoek, M, Wennekes, T, Narayan, RS, Speijer, D, Hollak, CE, Overkleeft, HS, Boot, RG, Aerts, JM	Blood Cells Mol Dis	2011