Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)

Stable Identifier
R-HSA-1861789
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Human glucosylceramidase 3 (GBA3) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide in the cytosol. GBA3 may be involved in the intestinal absorption and metabolism of dietary flavonoid glycosides (Berrin et al. 2002, Nemeth et al. 2003).

Literature References
PubMed ID Title Journal Year
11784319 Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides

Berrin, JG, McLauchlan, WR, Needs, P, Williamson, G, Puigserver, A, Kroon, PA, Juge, N

Eur J Biochem 2002
12594539 Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans

Nemeth, K, Plumb, GW, Berrin, JG, Juge, N, Jacob, R, Naim, HY, Williamson, G, Swallow, DM, Kroon, PA

Eur J Nutr 2003
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Catalyst Activity
Title
glucosylceramidase activity of GBA3 [cytosol]
Physical Entity
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