Reactome | GBA2 hydrolyzes GlcCer (plasma membrane)

GBA2 hydrolyzes GlcCer (plasma membrane)

Stable Identifier

R-HSA-1861788

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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GBA2 hydrolyzes GlcCer (plasma membrane)

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Human glucosylceramidase 2 (GBA2) hydrolyzes the glucosidic bond of glucocerebrosides (GlcCer) to form ceramide at the plasma membrane (Matern et al. 2001, Boot et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17105727	Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2 Verhoek, M, van Marle, J, Boot, RG, Overkleeft, HS, Donker-Koopman, W, Strijland, A, Aerts, JM, Wennekes, T	J Biol Chem	2007
11489889	Molecular cloning and expression of human bile acid beta-glucosidase Matern, S, Matern, H, Boermans, H, Lottspeich, F	J Biol Chem	2001