Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)

Stable Identifier
R-HSA-1861788
Type
Reaction [transition]
Species
Homo sapiens
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Human glucosylceramidase 2 (GBA2) hydrolyses the glucosidic bond of glucocerebrosides to form ceramide at the plasma membrane (Matern et al. 2001, Boot et al. 2007).

Literature References
PubMed ID Title Journal Year
11489889 Molecular cloning and expression of human bile acid beta-glucosidase

Matern, H, Boermans, H, Lottspeich, F, Matern, S

J Biol Chem 2001
17105727 Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2

Boot, RG, Verhoek, M, Donker-Koopman, W, Strijland, A, van Marle, J, Overkleeft, HS, Wennekes, T, Aerts, JM

J Biol Chem 2007
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Catalyst Activity
Title
glucosylceramidase activity of GBA2 [plasma membrane]
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