IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
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Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1/2 (PPIP5K1) and 2 (PPIP5K2) phosphorylate inositol 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1-diphospho-2,3,4,5,6-pentakisphosphate (1-PP-IP5)) (Fridy et al. 2007, Mulugu et al. 2007, Choi et al. 2007, Lin et al. 2009; Wang et al. 2011).

Literature References
PubMed ID Title Journal Year
18981179 Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases

Falck, JR, Ribeiro, AA, Mayr, GW, Choi, JH, York, JD, Vogel, G, Barma, DK, Fridy, PC, Shears, SB, Lin, H

J Biol Chem 2009
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Cho, J, Williams, J, Falck, JR, Choi, JH, Shears, SB

J Biol Chem 2007
17690096 Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases

Dollins, DE, Otto, JC, York, JD, Fridy, PC

J Biol Chem 2007
22119861 Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding

Falck, JR, Wang, H, Shears, SB, Hall, TM

Nat. Chem. Biol. 2012
17412958 A conserved family of enzymes that phosphorylate inositol hexakisphosphate

Haystead, TA, Dollins, DE, Ribeiro, AA, Otto, JC, Bai, W, York, JD, Mulugu, S, Fridy, PC, Bastidas, RJ

Science 2007
Catalyst Activity

inositol hexakisphosphate kinase activity of PPIP5K1/2 [cytosol]

Orthologous Events
Cross References
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