I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol

Stable Identifier
R-HSA-1855172
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
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The broad-specificity enzyme inositol-tetrakisphosphate 1-kinase (ITPK1) phosphorylates inositol 1,3,4-trisphosphate (I(1,3,4)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Wilson & Majerus 1996).
Literature References
PubMed ID Title Journal Year
8662638 Isolation of inositol 1,3,4-trisphosphate 5/6-kinase, cDNA cloning and expression of the recombinant enzyme

Majerus, PW, Wilson, MP

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

inositol-1,3,4-trisphosphate 5-kinase activity of ITPK1:Mg2+ [cytosol]

Physical Entity
ITPK1:Mg2+ [cytosol] (Homo sapiens)
Activity
inositol-1,3,4-trisphosphate 5-kinase activity (GO:0052726)
Orthologous Events
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Bos taurus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Canis familiaris)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Danio rerio)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Gallus gallus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Mus musculus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Rattus norvegicus)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Sus scrofa)
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
Williams, MG  (2011-10-28)
Created
Williams, MG  (2011-10-28)
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