I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol

Stable Identifier
R-HSA-1855169
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
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Inositol-tetrakisphosphate 1-kinase (ITPK1) phosphorylates inositol 3,4,6-trisphosphate (I(3,4,6)P3) to inositol 1,3,4,6-tetrakisphosphate (I(1,3,4,6)P4) (Ho et al. 2002).

Literature References
PubMed ID Title Journal Year
11909533 Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase

Zhang, T, Kwon, YU, Potter, BV, Carew, MA, Chung, SK, Riley, AM, Vogel, G, Hua, L, Ho, MW, Yang, X, Shears, SB, Adelt, S

Curr Biol 2002
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Catalyst Activity

inositol-3,4,6-trisphosphate 1-kinase activity of ITPK1:Mg2+ [cytosol]

Physical Entity
ITPK1:Mg2+ [cytosol] (Homo sapiens)
Activity
inositol-3,4,6-trisphosphate 1-kinase activity (GO:0052835)
Orthologous Events
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Canis familiaris)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Danio rerio)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Dictyostelium discoideum)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Gallus gallus)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Mus musculus)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Rattus norvegicus)
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol (Sus scrofa)
Authored
Williams, MG  (2011-10-28)
Created
Williams, MG  (2011-10-28)
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