IPs transport between ER lumen and nucleus

Stable Identifier
Homo sapiens
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Inositol phosphates IP4 and IP5 are exported from the endoplasmic reticulum (ER) lumen to the nucleus (Caffrey et al. 1999, Chi et al. 1999, Nalaskowski et al. 2002, Verbsky et al. 2002, Brehm et al. 2007, Choi et al. 2007). The molecular details of these transport processes remain uncertain.
Literature References
PubMed ID Title Journal Year
17705785 Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase

Nalaskowski, MM, Windhorst, S, Schenk, TM, Kobras, M, Brehm, MA, Mayr, GW, Zhou, X, Shears, SB, Lin, H, Fanick, W

Biochem J 2007
10087200 Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19

Chi, H, Reynolds, PR, O'keefe, RJ, Romano, PR, Rosier, RN, Wang, J, Tiller, GE, Dasouki, MJ, Puzas, JE

Genomics 1999
9923613 The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification

Hidaka, K, Matsuda, M, Caffrey, JJ, Hirata, M, Shears, SB

FEBS Lett 1999
17702752 Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress

Cho, J, Williams, J, Falck, JR, Choi, JH, Shears, SB

J Biol Chem 2007
12084730 The synthesis of inositol hexakisphosphate. Characterization of human inositol 1,3,4,5,6-pentakisphosphate 2-kinase

Wente, SR, Majerus, PW, Kisseleva, MV, Wilson, MP, Verbsky, JW

J Biol Chem 2002
12027805 The human homologue of yeast ArgRIII protein is an inositol phosphate multikinase with predominantly nuclear localization

Nalaskowski, MM, Deschermeier, C, Mayr, GW, Fanick, W

Biochem J 2002
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